>Myxine_IGF gi|124266|sp|P22618.1|IGF_MYXGL RecName: Full=Insulin-like growth factor; Short=IGF; Flags: Precursor
-----------------YIRRVRQGSIYSLLVESQQWCKLTLTLLLL--L-----ALLTR
CTLSETLCGSELVDTLQFVCDDRGFFFVPQHVP---------------------------
------------------------------------------------------------
--------PRRGAHRRSRARKGIVEECCFKGCSLRLLEMYCAR--PSKAERDVARPRQR-
PHRASQHS----------------------------RRGSQSRGRGRSR-----------
-----------------------------------------
>Branchiostoma_IGF gi|289541368|gb|ADD09807.1| insulin-like growth factor [Branchiostoma belcheri]
------------------------------------------------------------
---AEYLCGSTLADVLSFVCGNRGYNSQPRRSL---GERA--------------------
----------------------IDFISEQQA-----------------------------
-------KDYMGSMPPVRRRRGLVEECCLNVCDYSHLESYCNPHPTAPAT--ASPVRTTE
SQPEEQERDEELAPLDGMVGDQAPLGSIENIENLVYHY-----DRDDITVDAAKKEPKMK
LKEILGSFEDKKANPVFP-----------------------
>Petromyzon_IGF gi|22830883|dbj|BAC15764.1| Insulin-like growth factor precursor [Petromyzon marinus]
-----M---EYKGLASCSLCRFTFRTTRTAAVGCTAARPLTLLAPLLLML-LLGAGNSRP
VRASETLCGSELVDALQFVCGDRGFYFVRHPSS-R-------------------------
------------------------------------------------------------
--------------SHGRPKKGIVEECCFSKCDLRLLEMYCAK--PAKSERDVRPPSFK-
HIET--------------------------------------------------------
-----------------------------------------
>Xenopus_IGF1 gi|254281238|ref|NP_001156865.1| insulin-like growth factor I-A precursor [Xenopus laevis]
METNNN---LSTQLFKCYFCDILKLK-------MHKMSCIH--LLYLVLC-FLTLTHS-A
AAGPETLCGAELVDTLQFVCGDRGFYFSKPTG----------------------------
------------------------------------------------------------
----------YGSNNRRSHHRGIVDECCFQSCDFRRLEMYCAPAKPAKSARSVRAQRHT-
DMPKAQ--------------------KEV-------HPKNTSRGNTGSRG------FRM-
-----------------------------------------
>Carassius_IGF1 gi|3982553|gb|AAC83443.1| insulin-like growth factor-I [Carassius auratus]
-----M---SSIHFFQGHWCDVFKCT-------MRCLSCTH--TLSLLLC-VLALTPATL
EAGPETLCGAELVDTLQFVCGDRGFYFSKPTG----------------------------
------------------------------------------------------------
----------YGPNSRRSHNRGIVDECCFQSCELRRLEMYCAPVKPGKTPRSLRAQRHT-
DGTRTAKKP-----ICG-HS--HSSCKEV-------HQKNSSRGNTGGRN------YRM-
-----------------------------------------
>Oryctolagus_IGF2 gi|284005088|ref|NP_001164877.1| insulin-like growth factor II precursor [Oryctolagus cuniculus]
-------------------------------MGLPMG---KSMPVLLTFLAFALCCI-AA
YRPSETLCGGELVDTLQFVCGDRGFYFSRPASR---------------------------
------------------------------------------------------------
-----------VN----RRSRGIVEECCFRSCDLALLETYCAT--PAKSERDVSNSLTT-
VLPDS------------LPD--YSVGKLF--QLDTGKR-SAQRLRRGLPALLPAHRGRLL
AKELEVSREAKHHQPQFLQPEGDAAHGAASP-EASSNQK--
>Myxine_INS gi|124650|sp|P01342.1|INS_MYXGL RecName: Full=Insulin; Contains: RecName: Full=Insulin B chain; Contains: RecName: Full=Insulin A chain; Flags: Precursor
---------------------------------MALSPFLAAVIPLV-LL-LSRAPPSAD
TRTTGHLCGKDLVNALYIACGVRGFFYDPTKMK-RDTGAL--------------------
----------------------AAFLPLAYAEDN-----------------------E-S
-----QDDESIGINEVLKSKRGIVEQCCHKRCSIYDLENYCN------------------
------------------------------------------------------------
-----------------------------------------
>Oryctolagus_IGF1 gi|12644472|sp|Q95222.3|IGF1_RABIT RecName: Full=Insulin-like growth factor I; Short=IGF-I; AltName: Full=Somatomedin; Flags: Precursor
-------------------MITPTVK-------MRILSSSH--LFYLALC-LLTFTSS-A
TAGPETLCGAELVDALQFVCGDRGFYFNKPTG----------------------------
------------------------------------------------------------
----------YGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKAARSVRAQRHT-
DMPKTQ--------------------KYQ-------PPSTNKKMKSQRRR--KGSTFEEH
K----------------------------------------
>Petromyzon_INS gi|60392464|sp|P68987.1|INS_PETMA RecName: Full=Insulin; Contains: RecName: Full=Insulin B chain; Contains: RecName: Full=Insulin A chain
--------------------------------------------------------SALT
GAGGTHLCGSHLVEALYVVCGDRGFFYTPS------------------------------
------------------------------------------------------------
-------------------KTGIVEQCCHRKCSIYDMENYCN------------------
------------------------------------------------------------
-----------------------------------------
>Xenopus_relax gi|169790790|ref|NP_001116073.1| relaxin 3 precursor [Xenopus (Silurana) tropicalis]
---------------------------------MQRVAPALLVVLWLLAWHSGTQATSRV
PTFGVKLCGREFIRAVIFTCGGSRWRRNEALQAASLVGEPAEVFGNLVSPDVNSDEEDVL
--SEWASSL-----R--PHNNDIDYGSVQSWRDTA--------------GGRH----GMA
AA---EDALRGVERRGREAALGLSNTCCKWGCSKSQISSLC-------------------
------------------------------------------------------------
-----------------------------------------
>Danio_relax gi|342316035|gb|AEL22115.1| relaxin [Danio rerio]
---------------------------------MFRVCPALLLVCVSVFGLCVCVSADLP
RDFGVKLCGREFIRAVIFTCGGSRWRRADTPSGEVWLDPQQDTLDGAGSPEVGSPDAGSP
GSHRWSLSGVLQLLA--GARVRAPQIGLRAWLQTL--------------SS--------S
SS---GPAWPRPDRRKRNFSVGLAGMCCNQGCTKNDIGRLC-------------------
------------------------------------------------------------
-----------------------------------------
>Danio_IGF1 162 CDS /gene="igf1" /locus_tag="CH211-260P3.4-001" /standard_name="OTT
-----M---SSGHFFQGHWCDVFKCT-------MRCLPSTH--TLSLVLC-VLALTPATL
EAGPETLCGAELVDTLQFVCGDRGFYFSKPTG----------------------------
------------------------------------------------------------
----------YGPSSRRSHNRGIVDECCFQSCELRRLEMYCAPVKTGKSPRSLRAQRHT-
DIPRTPKKP-----ISG-HS--HSSCKEV-------HQKNSSRGNTGGRN------YRM*
-----------------------------------------
>Equus_IGF1 154 CDS /codon_start=1 /product="insulin-like growth factor 1" /note="I
MGKISS---LPTQLFKCCFCDFLKVK-------MHIMSSSH--LFYLALC-LLTFTSS-A
TAGPETLCGAELVDALQFVCGDRGFYFNKPTG----------------------------
------------------------------------------------------------
----------YGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHT-
DMPKAQ--------------------KEV-------HLKNASRGSAGNKN------YRM*
-----------------------------------------
>Anas_IGF1 154 CDS /codon_start=1 /product="insulin-like growth factor 1" /note="I
MEEINS---LSTQLVKCCFCDFLKVK-------MHTVSYIH--FFYLGLC-LLTLTSS-V
AAGPETLCGAELVDALQFVCGDRGFYFSKPTG----------------------------
------------------------------------------------------------
----------YGSSSRRLHHKGIVDECCFQSCDLRRLEMYCAPIKPPKSARSVRAQRHT-
DMPKAQ--------------------KEV-------HLKNTSRGNTGNRN------YRM*
-----------------------------------------
>Vulpes_IGF1 154 CDS /codon_start=1 /gene="IGF1" /product="insulin-like growth facto
MGKISS---LPTQLFKCCFCDFLKVK-------MHTVSSSH--LFYLALC-LLTFPSP-A
TAGPETLCGAELVDALQFVCGDRGFYFNKPTG----------------------------
------------------------------------------------------------
----------YGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHT-
DMPKAQ--------------------KEV-------HLKNASRGSAGNKN------YRM*
-----------------------------------------
>Eospalax_IGF1 154 CDS /codon_start=1 /product="insulin-like growth factor 1" /note="I
MGKISS---LPTQLFKCCFCDFLKVK-------MRIRSLSH--LFYLALC-LLTFTSS-A
TAAPETLCGAELVDALQFVCGDRGFYFNKPIG----------------------------
------------------------------------------------------------
----------YGSSSRRAQQTGIVDECCFRGCDLRRPEMYCAPLKSAKAARSVRAQRHT-
DMPKTQ--------------------KEV-------HLKNTSRGNAGNKS------YRM*
-----------------------------------------
>Ochotona_IGF1 154 CDS /codon_start=1 /product="insulin-like growth factor 1" /note="I
MGKISS---LPTQLFKCCSCDFLKVK-------MRIRPLSH--LFYLALC-LLTFTSS-A
TAAPETLCGAELVDALQFVCGDRGFYFNKPIG----------------------------
------------------------------------------------------------
----------YGSSSRRAQQTGIVDECCFRSCDLRRLEMYCAPLKSAKAARSVRAQRHT-
DMPKTQ--------------------KEV-------HLKNTSRGNAGNKS------YRM*
-----------------------------------------
>Microtus_IGF1 154 CDS /codon_start=1 /product="insulin-like growth factor 1" /db_xref
MGKVTG---LPAQLFKCCFCDFLKIK-------MHTMSSSH--LFYLALC-LLTFTSS-A
TAGPETLCGAELVDALQFVCGPRGFYFNKPTG----------------------------
------------------------------------------------------------
----------YGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKSARSIRAQRHT-
DMPKTQ--------------------KEV-------HLKNASRGSAGNKN------YRM*
-----------------------------------------
>Homo_IGF1 154 CDS /codon_start=1 /gene="IGF1" /product="insulin-like growth facto
MGKISS---LPTQLFKCCFCDFLKVK-------MHTMSSSH--LFYLALC-LLTFTSS-A
TAGPETLCGAELVDALQFVCGDRGFYFNKPTG----------------------------
------------------------------------------------------------
----------YGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHT-
DMPKTQ--------------------KEV-------HLKNASRGSAGNKN------YRM*
-----------------------------------------
>Equus_IGF2 182 CDS /codon_start=1 /gene="IGF2" /product="insulin-like growth facto
-------------------------------MGIPVG---KSLLMLFTFLAFASCCI-AA
YRPSETLCGGELVDTLQFVCGDRGFYFSRPASR---------------------------
------------------------------------------------------------
-----------IN----RRSRGIVEECCFRSCDLALLETYCAT--PAKSERDVSTP-PT-
VLPDD------------SPR--YPVVKLF--QYNAWKQ-STQRLRRGLPALLRTRRGRML
VKELEAFREAQRHRPLIALPTEDPTPHGAAFVEVSSDLQ*-
>Xenopus_IGF2 218 CDS /codon_start=1 /product="insulin-like growth factor 2" /note="I
MEQLSCKHRSSSVEAEAQLCRQTESRSTQLPRMSVMR---HLFLLSITFLVYTLDSA-KA
YRATETLCGGELVDTLQFVCGDRGFYFSTNNGR---------------------------
------------------------------------------------------------
-----------SN---RRPNRGIVDVCCFKSCDLELLETYCAK--PTKNERDVSTAPAT-
AIPPLSK-------QDLYHK--HHHTKSS--KYDIWQRKSIHRLRRGVPAIVRARQYRLL
MEKAEEAEQALSHRPLTTLPITRPLRLQQASEPSH-N*---
>Mus_IGF2 181 CDS /gene="IGF2" /locus_tag="XX-CH35_17P24.2-002" /standard_name="O
-------------------------------MGIPVG---KSMLVLLISLAFALCCI-AA
YGPGETLCGGDLVDTLQFVCSDRGFYFSRPSSR---------------------------
------------------------------------------------------------
-----------AN----RRSRGIVEECCFRSCDLALLETYCAT--PAKSERDVSTS-QA-
VLPDD------------FPR--YPVGKFF--QYDTWRQ-SAGRLRRGLPALLRARRGRML
AKELKAFSEAKRHRPLIVLPPKDPAHGGASS-EMSSNHQ*-
>Monodesphis_IGF2 187 CDS /codon_start=1 /gene="IGF2" /product="insulin-like growth facto
-------------------------------MGFPTK---KMLLLSLTFLAFASCCD-AA
YRPSETLCGGELVDTLQFVCGDRGFYFSLPGRP---------------------------
------------------------------------------------------------
-----------LSRVSRRLNRGIVEECCFRSCDLALLETYCAT--PAKSERDLSAS-MM-
VLPDN------------FPR--FPVGRFF--KLDTWQK-SAHRLRRGLPALLRARRDRLR
AQALDAIREAKRHRPLISLPSGDPLRAELAAASEKAARQK*
>Cervus_IGF2 Cervus elaphus insulin-like growth factor 2 mRNA, complete cds.
-------------------------------MGIPVG---KSVLAFLTFLAFASCCY-AA
YRPSETLCGGELVDTLQFVCGDRGFYFSRPSSR---------------------------
------------------------------------------------------------
-----------IN----RRSRGIVEECCFRSCDLALLETYCAT--PAKSERDVSAS-TT-
VLPDD------------LTA--YPVGKLF--RHDTRKQ-STQRLRRGLPAFLRARRGRTL
AQELEALREAKSHRPLITLPIQDPATHGGASSEASSD*---
>Bos_IGF2 180 CDS /codon_start=1 /gene="IGF2" /product="insulin-like growth facto
-------------------------------MGITAG---KSVLVLLAFLAFASCCY-AA
YRPSETLCGGELVDTLQFVCGDRGFYFSRPSSR---------------------------
------------------------------------------------------------
-----------IN----RRSRGIVEECCFRSCDLALLETYCAT--PAKSERDVSAS-TT-
VLPDD------------VTA--YPVGKFF--QYDIWKQ-STQRLRRGLPAFLRARRGRTL
AKELEALREAKSHRPLIALPTQDPATHGGASSKASSD*---
>Carassius_IGF2 202 CDS /codon_start=1 /product="insulin-like growth factor 2" /note="I
MD---------DCHLFCASCRKTVE-----------R---QTMMRSLILFSLSLCTFASP
VATTETLCGGELVDTLQFVCGADGFYISKPNRF---------------------------
------------------------------------------------------------
-----------NG---RRPQTGIVEECCFRSCELRLLQQYCAK--PVKSERDVSSSSLQ-
AFPASQALH-----KDISEG--QLGVKYS--KYEVWQRKAAQRLRRGVPSILLARKFRRQ
MEKIQDEEQARFHRPLMTLPDRHPAIRPQIQINTSHK*---
>Homo_IGF2 181 CDS /codon_start=1 /gene="IGF2" /product="insulin-like growth facto
-------------------------------MGIPMG---KSMLVLLTFLAFASCCI-AA
YRPSETLCGGELVDTLQFVCGDRGFYFSRPASR---------------------------
------------------------------------------------------------
-----------VS----RRSRGIVEECCFRSCDLALLETYCAT--PAKSERDVSTP-PT-
VLPDN------------FPR--YPVGKFF--QYDTWKQ-STQRLRRGLPALLRARRGHVL
AKELEAFREAKRHRPLIALPTQDPAHGGAPP-EMASNRK*-
>Danio_INS 109 CDS /gene="ins" /product="insulin" /function="metabolic homeostasis
---------------------------------MAVWIQAGALLVL-----LVVSSVSTN
PGTPQHLCGSHLVDALYLVCGPTGFFYNPKRD----VEPL--------------------
----------------------LGFLPPKSAQET-----------------------E-V
-----A-DFAFKDHAELIRKRGIVEQCCHKPCSIFELQNYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Spermophilus_INS 111 CDS /codon_start=1 /product="insulin" /note="metabolic hormone"
---------------------------------MALW---TRLLPLLALL-ALLGPDPAQ
AFVNQHLCGSHLVEALYLVCGERGFFYTPKSRR-EVEEQQ--------------------
----------------------GGQVELGGGPGA-----------------------G--
-------LPQPLALEMALQKRGIVEQCCTSICSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Bos_INS 106 CDS /codon_start=1 /gene="INS" /product="insulin" /db_xref="GOA:A5P
---------------------------------MALW---TRLAPLLALL-ALWAPAPAR
AFVNQHLCGSHLVEALYLVCGERGFFYTPKARR-EVEGPQ--------------------
----------------------VGALELAGGPGA-----------------------G--
-------GL-----EGPPQKRGIVEQCCASVCSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Homo_INS 111 CDS /codon_start=1 /gene="INS" /product="insulin" /note="precursor"
---------------------------------MALW---MRLLPLLALL-ALWGPDPAA
AFVNQHLCGSHLVEALYLVCGERGFFYTPKTRR-EAEDLQ--------------------
----------------------VGQVELGGGPGA-----------------------G--
-------SLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Ovis_INS 106 CDS /codon_start=1 /product="insulin" /db_xref="GOA:P01318" /db_xref=
---------------------------------MALW---TRLVPLLALL-ALWAPAPAH
AFVNQHLCGSHLVEALYLVCGERGFFYTPKARR-EVEGPQ--------------------
----------------------VGALELAGGPGA-----------------------G--
-------GL-----EGPPQKRGIVEQCCAGVCSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Oryctolagus_INS 111 CDS /codon_start=1 /product="insulin" /db_xref="GOA:P01311" /db_xref=
---------------------------------MASL---AALLPLLALL-VLCRLDPAQ
AFVNQHLCGSHLVEALYLVCGERGFFYTPKSRR-EVEELQ--------------------
----------------------VGQAELGGGPGA-----------------------G--
-------GLQPSALELALQKRGIVEQCCTSICSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Mus_mus_INS CDS /gene="Ins2" /gene_synonym="proinsulin" /codon_start=1 /produc
---------------------------------MALW---MRFLPLLALL-FLWESHPTQ
AFVKQHLCGSHLVEALYLVCGERGFFYTPMSRR-EVEDPQ--------------------
----------------------VAQLELGGGPGA-----------------------G--
-------DLQTLALEVAQQKRGIVDQCCTSICSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Mus_sprec_INS 111 CDS /gene="INS2" /locus_tag="XX-CH35_17P24.1-001" /standard_name="
---------------------------------MALW---MRFLPLLALL-FLWESHPTQ
AFVKQHLCGSHLVEALYLVCGERGFFYTPMSRR-EVEDPQ--------------------
----------------------VAQLELGGGPGA-----------------------G--
-------DLQTLALEVAQQKRGIVDQCCTSICSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Rattus_INS 111 CDS /gene="INS2" /note="precursor" /codon_start=1 /product="insuli
---------------------------------MALW---IRFLPLLALL-ILWEPRPAQ
AFVKQHLCGSHLVEALYLVCGERGFFYTPMSRR-EVEDPQ--------------------
----------------------VAQLELGGGPGA-----------------------G--
-------DLQTLALEVARQKRGIVDQCCTSICSLYQLENYCN*-----------------
------------------------------------------------------------
-----------------------------------------
>Canis_relax 178 Canis familiaris relaxin mRNA, complete cds.
---------------------------------MLRWFLSHLLGVWLLLSQLPREIPAT-
DDKKLKACGRDYVRLQIEVCGSIWWGRKAGQLRERRQISEP--LAEVVPSSIINDPEILS
LMLQSIPGMPQELRIATRSGKEKLLREL---HFVLEDSNLNLEEMKKTFLNTQFEAEDKS
LSK-----LDKHPRKKRDNYIKMSDKCCNVGCTRRELASRC*------------------
------------------------------------------------------------
-----------------------------------------
>Felis_relax 181 Felis catus relaxin mRNA, complete cds.
---------------------------------MLRLFLSHLLGVWLLLSLRARKIPAQ-
E-EVLKACGREFVRLQIRICGSLSWGKSSQQHREPRQAPAA--LPEIVSSSITSGAEALN
GMLEYIPDLPQELKAT-LSEREPSFREL---QPSLKDSNLNLEEVEKSILGRQNEAEDQS
LSQLGRSRLDAHSRIKRSDYIRYSDRCCNVGCTRKELADLC*------------------
------------------------------------------------------------
-----------------------------------------
>Rana_relax 156 CDS /gene="rlx" /product="relaxin" /db_xref="GOA:Q9DEP8" /db_xref="
-------------------------------MSLHFCLFALLLTLAIPVWC----QGMDV
SDVGIRLCGRDFIRTVVMSCGGSRWKRYSPEPGQERSNPNRDFLDWLNRASLEDPDRLNS
---LYAESH---------MAPNPPFSSLQKDDPTM--------------EQLH----GAL
YDPLVTEEQQGVG-LRMKRSAGPALSCCQRGCTKNELMKFC*------------------
------------------------------------------------------------
-----------------------------------------
>Macaca_relax 186 Macaca mulatta relaxin (RLN) mRNA, complete cds.
---------------------------------MPRLFLFHLLGVCLLLNQFSRAVAAKW
MDDVIKACGRELVRAQIAICGKSTLGKRSLNQEDAPLKPRP--AAEIVPSLINQDTETIN
MMSEFVANLPQELKLT-LSERQPALSELQQHVPVLKDSNLSFEEFKKIIRKRQSEATDSS
PSELKSLGLDTHSRRKRQLYMTLSNKCCHIGCTKKSLAKFC*------------------
------------------------------------------------------------
-----------------------------------------
>Homo_relax 186 Human mRNA for prepro-relaxin H2
---------------------------------MPRLFFFHLLGVCLLLNQFSRAVADSW
MEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRP--VAEIVPSFINKDTETIN
MMSEFVANLPQELKLT-LSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSS
PSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC*------------------
------------------------------------------------------------
-----------------------------------------