ID   BCL2_3UT       SEQUENCES:   4; ALIGNED BASES:  5437.
AC   CU00001;
DT   10-JUN-1996  (CREATED)
DT   10-JUN-1996  (LAST UPDATE)
XX
DE   B-CELL LEUKEMIA/LYMPHOMA 2 (BCL-2) PROTO-ONCOGENE, ALPHA ISOFORM 3'UTR.
AG   310 MYRS (MAMMALIA/SAUROPSIDA).
LO   3'UTR (STOP CODON TO POLYADENYLATION SITE).
KW   APOPTOSIS;
XX
CC   -!- PROTEIN FUNCTION :PROLONGS THE SURVIVAL OF HEMATOPOIETIC CELLS IN 
CC       THE ABSENCE OF REQUIRED GROWTH FACTORS AND ALSO IN THE PRESENCE OF 
CC       VARIOUS STIMULI INDUCING CELLULAR DEATH. BLOCKS APOPTOSIS. MIGHT 
CC       FUNCTION IN AN ANTIOXIDANT PATHWAY TO PREVENT APOPTOSIS AT SITES OF 
CC       FREE RADICAL GENERATION SUCH AS MITOCHONDRIA.
XX
CC   -!- PROTEIN SUBCELLULAR LOCATION: MITOCHONDRIAL INNER MEMBRANE (BY 
CC       SIMILARITY).
XX
CC   -!- GENE EXPRESSION: EXPRESSED IN A VARIETY OF TISSUES.
XX
CC   ALTERNATIVE PRODUCTS: TWO FORMS OF BCL2-2: ALPHA, AND BETA, ARE PRODUCED 
CC   BY ALTERNATIVE SPLICING OF THE SAME GENE. THEY ONLY DIFFER AT THEIR 
CC   3' ENDS.
XX
SN   [1]
SI   BCL2_3UT.1.CHICK
SL   1011.
OS   GALLUS GALLUS (CHICKEN).
TX   SAUROPSIDA (BIRDS AND REPTILES).
DR   EMBL; D11382. gene; BCL2
DR   EMBL; Z11961. mRNA; PCKBCL2
XX
SN   [2]
SI   BCL2_3UT.1.HUMAN
SL   2908.
OS   HOMO SAPIENS (HUMAN).
TX   MAMMALIA.
DR   EMBL; M13994. mRNA;  B-cell leukemia/lymphoma 2 (bcl-2) proto-oncogene
DR   EMBL; M14745. mRNA;  
XX
SN   [3]
SI   BCL2_3UT.1.MOUSE
SL   5270.
OS   MUS MUSCULUS (MOUSE).
TX   MAMMALIA.
DR   EMBL; L31532. gene; bcl-2 alpha
XX
SN   [4]
SI   BCL2_3UT.1.RAT
SL   234.
OS   RATTUS NORVEGICUS (RAT).
TX   MAMMALIA.
DR   EMBL; L14680. mRNA; bcl-2
XX
FT   3'UTR           1..>5437
FT   HCR310          169..264
FT                   /name="HCR310_1"
FT                   /average_identity="75.7 %"
FT                   /score="233"
FT   HCR310          938..1162
FT                   /name="HCR310_2"
FT                   /average_identity="58.3 %"
FT                   /score="278"
//