ID   ACTSA_5NC      SEQUENCES:   4; ALIGNED BASES:  5657.
AC   CU00073;
DT   21-JUN-1996  (CREATED)
DT   21-JUN-1996  (LAST UPDATE)
XX
DE   ACTIN, AORTIC SMOOTH MUSCLE (ALPHA-ACTIN) PROMOTER REGION AND FIRST 
DE   INTRON.
AG   310 MYRS (MAMMALIA/SAUROPSIDA).
LO   5'NON-CODING REGION (5' OF START CODON).
KW
XX
CC   -!- PROTEIN FUNCTION :ACTINS ARE HIGHLY CONSERVED PROTEINS THAT ARE 
CC       INVOLVED IN VARIOUS TYPES OF CELL MOTILITY AND ARE UBIQUITOUSLY 
CC       EXPRESSED IN ALL EUKARYOTIC CELLS.
XX
CC   -!- PROTEIN SUBCELLULAR LOCATION: CYTOPLASMIC.
XX
CC   IN VERTEBRATES 3 MAIN GROUPS OF ACTIN ISOFORMS, ALPHA, BETA AND GAMMA 
CC   HAVE BEEN IDENTIFIED. THE ALPHA ACTINS ARE FOUND IN MUSCLE TISSUES 
CC   AND ARE A MAJOR CONSTITUENT OF THE CONTRACTILE APPARATUS. THE BETA 
CC   AND GAMMA ACTINS CO-EXISTS IN MOST CELL TYPES AS COMPONENTS OF THE 
CC   CYTOSKELETON AND AS MEDIATORS OF INTERNAL CELL MOTILITY.
XX
CC   -!- BEST SCORE: 646.
XX
CC   THERE ARE 2 CONSERVED REGIONS IN ACTSA GENE 5'NON CODING PART. THE FIRST 
CC   IS LOCATED IN THE PROMOTER REGION. THE SECOND IS FOUND IN THE FIRST 
CC   INTRON AND MAY BE AN ENHANCER [1].
XX
RN   [1]
RX   MEDLINE; 91216472.
RA   Nakano Y., Nishihara T., Sasayama S., Miwa T., Kamada S., Kakunaga T.;
RT   "Transcriptional regulatory elements in the 5' upstream and first intron
RT   regions of the human smooth muscle (aortic type) alpha-actin-encoding 
RT   gene";
RL   Gene 99:285-289(1991).
XX
SN   [1]
SI   ACTSA_5NC.1.CHICK
SL   3356.
OS   GALLUS GALLUS (CHICKEN).
TX   SAUROPSIDA (BIRDS AND REPTILES).
DR   EMBL; D00041. gene; alpha-smooth muscle actin
DR   EMBL; M13756. gene; 
XX
SN   [2]
SI   ACTSA_5NC.1.HUMAN
SL   5586.
OS   HOMO SAPIENS (HUMAN).
TX   MAMMALIA.
DR   EMBL; D00618. gene; vascular smooth muscle alpha-actin (ACTSA)
DR   EMBL; J05193. gene; 
XX
SN   [3]
SI   ACTSA_5NC.1.MOUSE
SL   1146.
OS   MUS MUSCULUS (MOUSE).
TX   MAMMALIA.
DR   EMBL; M57409. gene; vascular smooth muscle alpha-actin (ACTSA)
XX
SN   [4]
SI   ACTSA_5NC.1.RAT
SL   764.
OS   RATTUS SP (RAT).
TX   MAMMALIA.
DR   EMBL; S76011. gene; vascular smooth muscle alpha-actin (ACTSA)
XX
FT   HCR310          1536..1765
FT                   /name="HCR310_1"
FT                   /average_identity="72.3 %"
FT                   /score="439"
FT   TATA_signal     1748..1754
FT   misc_feature    1776
FT                   /note="mRNA start site (cap site)"
FT   exon            1776..1823
FT   5'UTR           join(1776..1823,5615..5657)
FT   HCR310          1804..1873
FT                   /name="HCR310_2"
FT                   /average_identity="74.3 %"
FT                   /score="188"
FT   intron          1824..5614
FT   HCR310          2695..2750
FT                   /name="HCR310_3"
FT                   /average_identity="71.4 %"
FT                   /score="136"
FT   HCR310          2864..2958
FT                   /name="HCR310_4"
FT                   /average_identity="73.7 %"
FT                   /score="250"
FT   misc_signal     2898..2907
FT                   /note="CArG box0"
FT                   /citation=[1]
FT   exon            5615..>5657
//