ID A4_3UT SEQUENCES: 4; ALIGNED BASES: 1465. AC CU00092; DT 25-JUN-1996 (CREATED) DT 25-JUN-1996 (LAST UPDATE) XX DE BETA-AMYLOID PLAQUE CORE PROTEIN A4 3'UTR. AG 335 MYRS (AMNIOTA/AMPHIBIA). LO 3'UTR (STOP CODON TO POLYADENYLATION SITE). KW XX CC -!- PROTEIN FUNCTION :FUNCTIONAL NEURONAL RECEPTOR WHICH COUPLES TO CC INTRACELLULAR SIGNALING PATHWAY THROUGH THE GTP-BINDING PROTEIN G(O). XX CC -!- PROTEIN SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. XX CC -!- GENE EXPRESSION: UBIQUITOUS EXPRESSION; TISSUE SPECIFIC ALTERNATIVE CC SPLICING; IN XENOPUS, THERE IS A HIGH ACCUMULATION OF MATERNAL APP CC FROM EARLY OOGENESIS. AFTER FERTILIZATION, THE MRNA IS DEGRADED, CC REACHING A MINIMUM LEVEL AROUND THE GASTRULA STAGE. XX CC -!- BEST SCORE: 516. XX SN [1] SI A4_3UT.1.HUMAN SL 1346. OS HOMO SAPIENS (HUMAN). TX MAMMALIA. DR EMBL; M33112. gene; amyloid-beta protein DR EMBL; Y00264. mRNA; DR EMBL; X06989. mRNA; DR EMBL; A02759. mRNA; XX SN [2] SI A4_3UT.1.MACFA SL 867. OS MACACA FASCICULARIS (CRAB EATING MACAQUE). TX MAMMALIA. DR EMBL; M58727. mRNA; amyloid b-protein XX SN [3] SI A4_3UT.1.XENLA SL 717. OS XENOPUS (AFRICAN CLAWED FROG). TX AMPHIBIA. DR EMBL; S52417. mRNA; beta-amyloid precursor protein APP751 XX SN [4] SI A4_3UT.1.MOUSE SL 902. OS MUS MUSCULUS (MOUSE). TX MAMMALIA. DR EMBL; X59379. mRNA; amyloid beta precursor (protease nexin II) XX FT 3'UTR 1..985 FT HCR335 151..250 FT /name="HCR335_1" FT /average_identity="70.7 %" FT /score="217" FT HCR335 267..364 FT /name="HCR335_2" FT /average_identity="72.7 %" FT /score="222" FT HCR335 407..455 FT /name="HCR335_3" FT /average_identity="71.4 %" FT /score="119" FT HCR335 662..739 FT /name="HCR335_4" FT /average_identity="76.3 %" FT /score="214" FT polyA_signal 965..970 FT polyA_signal 974..979 //