ID ACTB_3UT SEQUENCES: 10; ALIGNED BASES: 1251. AC CU00100; DT 26-JUN-1996 (CREATED) DT 26-JUN-1996 (LAST UPDATE) XX DE ACTIN, CYTOPLASMIC BETA, 3'UTR AND 3'FLANK. AG 400 MYRS (ACTINOPTERYGII/SARCOPTERYGII). LO 3'UTR (STOP CODON TO POLYADENYLATION SITE). KW STRUCTURAL PROTEIN; CYTOSKELETON; XX CC -!- PROTEIN FUNCTION :ACTINS ARE HIGHLY CONSERVED PROTEINS THAT ARE CC INVOLVED IN VARIOUS TYPES OF CELL MOTILITY AND ARE UBIQUITOUSLY CC EXPRESSED IN ALL EUKARYOTIC CELLS. XX CC -!- PROTEIN SUBCELLULAR LOCATION: CYTOPLASMIC. XX CC -!- GENE EXPRESSION: WIDELY EXPRESSED. XX CC -!- mRNA SUBCELLULAR LOCATION: SPECIFIC SUBCELLULAR LOCATION IN CHICKEN CC EMBRYONIC FIBROBLASTS AND MYOBLASTS [3][4]. XX CC -!- BEST SCORE: 469. XX CC BETA-ACTIN GENE 3'END AFFECTS TRANSCRIPTION [1][2]. BETA-ACTIN MRNA 3'UTR CC IS RESPONSIBLE FOR ITS SPECIFIC SUBCELLULAR LOCALIZATION [3][4]. CC CC BETA AND GAMMA CYTOPLASMIC ACTINS ARE FOUND IN ALL NONMUSCLE CELLS AND CC DIFFER BY ONLY FOUR AMINO ACIDS AT THE AMINO-TERMINAL REGION. BOTH CC GENES ARE REGULATED TEMPORALLY AND SPATIALLY, THOUGH NO DIFFERENCES IN CC PROTEIN FUNCTION HAVE BEEN DESCRIBED. THE TWO MRNAS HAVE DIFFERENT CC SUBCELLULAR LOCALIZATION IN MYOBLASTS [5]. THE TWO GENES HAVE TOTALLY CC DISTINCT BUT HIGHLY CONSERVED 3'UTRS (SEE CU00169). IT HAS BEEN PROPOSED CC THAT THE FUNCTIONAL SIGNIFICANCE OF THE DIFFERENT ACTIN ISOFORMS MAY CC INVOLVE THE PROPERTIES OF THEIR NONCODING REGIONS IN ADDITION TO THE CC DIFFERENCES IN PROTEIN SEQUENCE [6]. XX RN [1] RX MEDLINE; 88217501. RA Lohse P., Arnold H.H.; RT "The down-regulation of the chicken cytoplasmic beta actin during RT myogenic differentiation does not require the gene promoter but RT involves the 3' end of the gene"; RL Nucleic Acids Res. 16:2787-803(1988). XX RN [2] RX MEDLINE; 88144442. RA DePonti-Zilli L., Seiler-Tuyns A., Paterson B.M.; RT "A 40-base-pair sequence in the 3' end of the beta-actin gene regulates RT beta-actin mRNA transcription during myogenesis"; RL Proc. Natl. Acad. Sci. USA 85:1389-93(1988). XX RN [3] RX MEDLINE; 94012955. RA Kislauskis E.H., Li Z., Singer R.H., Taneja K.L.; RT "Isoform-specific 3'-untranslated sequences sort alpha-cardiac and RT beta-cytoplasmic actin messenger RNAs to different cytoplasmic RT compartments"; RL J. Cell. Biol. 123:165-72(1993). XX RN [4] RX MEDLINE; 95014735. RA Kislauskis E.H., Zhu X., Singer, R.H.; RT "Sequences responsible for intracellular localization of beta-actin RT messenger RNA also affect cell phenotype"; RL J. Cell. Biol. 127:441-451(1994). XX RN [5] RX MEDLINE; 93352696. RA Hill M.A., Gunning P.; RT "Beta and gamma actin mRNAs are differentially located within myoblasts"; RL J. Cell Biol. 122:825-32(1993). XX RN [6] RX MEDLINE; 93209992. RA Lloyd C., Gunning P.; RT "Noncoding regions of the gamma-actin gene influence the impact of the RT gene on myoblast morphology"; RL J. Cell Biol. 121:73-82(1993). XX SN [1] SI ACTB_3UT.1.ORYLA SL 1016. OS ORYZIAS LATIPES (MEDAKA FISH). TX ACTINOPTERYGII (BONY FISHES). DR EMBL; S74868. gene; beta-actin XX SN [2] SI ACTB_3UT.1.SPAAU SL 678. OS SPARUS AURATA (GILTHEAD SEA BREAM). TX ACTINOPTERYGII (BONY FISHES). DR EMBL; X89920. mRNA; beta-actin XX SN [3] SI ACTB_3UT.1.CTEID SL 917. OS CTENOPHARYNGODON IDELLA (GRASS CARP). TX ACTINOPTERYGII (BONY FISHES). DR EMBL; M25013. gene; beta-actin XX SN [4] SI ACTB_3UT.1.CYPCA SL 696. OS CYPRINUS CARPIO (COMMON CARP). TX ACTINOPTERYGII (BONY FISHES). DR EMBL; M24113. gene; beta-actin XX SN [5] SI ACTB_3UT.1.CHICK SL 871. OS GALLUS GALLUS (CHICKEN). TX SAUROPSIDA (BIRDS AND REPTILES). DR EMBL; X00182. gene; beta-actin XX SN [6] SI ACTB_3UT.1.HUMAN SL 646. OS HOMO SAPIENS (HUMAN). TX MAMMALIA. DR EMBL; M10277. gene; beta-actin DR EMBL; X63432. mRNA; DR EMBL; X00351. mRNA; XX SN [7] SI ACTB_3UT.1.RABIT SL 636. OS ORYCTOLAGUS CUNICULUS (RABBIT). TX MAMMALIA. DR EMBL; X60733. mRNA; beta-actin XX SN [8] SI ACTB_3UT.1.MOUSE SL 684. OS MUS MUSCULUS (MOUSE). TX MAMMALIA. DR EMBL; X03672. mRNA; beta-actin DR EMBL; J04181. mRNA; XX SN [9] SI ACTB_3UT.1.RAT SL 966. OS RATTUS NORVEGICUS (RAT). TX MAMMALIA. DR EMBL; V01217. gene; cytoplasmic beta-actin DR EMBL; J00691. gene; XX SN [10] SI ACTB_3UT.1.CRIGR SL 1107. OS CRICETULUS GRISEUS (CHINESE HAMSTER). TX MAMMALIA. DR EMBL; U20114. gene; beta-actin XX FT 3'UTR 1..787 FT misc_feature 1..57 FT /note="RNA zipcode" FT /function="responsible for mRNA intracellular localization" FT /citation=[4] FT HCR310 41..64 FT /name="HCR310_1" FT /average_identity="69.3 %" FT /score="73" FT HCR400 103..134 FT /name="HCR400_2" FT /average_identity="79.7 %" FT /score="95" FT HCR310 111..137 FT /name="HCR310_3" FT /average_identity="96.3 %" FT /score="126" FT HCR310 197..285 FT /name="HCR310_4" FT /average_identity="69.9 %" FT /score="215" FT HCR400 203..280 FT /name="HCR400_5" FT /average_identity="70.3 %" FT /score="193" FT HCR400 281..355 FT /name="HCR400_6" FT /average_identity="53.1 %" FT /score="91" FT HCR310 291..360 FT /name="HCR310_7" FT /average_identity="77.2 %" FT /score="174" FT misc_feature 304..346 FT /note="RNA zipcode" FT /function="responsible for mRNA intracellular localization" FT /citation=[4] FT HCR400 399..445 FT /name="HCR400_8" FT /average_identity="73.7 %" FT /score="139" FT HCR310 399..444 FT /name="HCR310_9" FT /average_identity="73.8 %" FT /score="137" FT HCR310 527..585 FT /name="HCR310_10" FT /average_identity="73.8 %" FT /score="143" FT HCR310 709..782 FT /name="HCR310_11" FT /average_identity="71.2 %" FT /score="176" FT HCR400 721..785 FT /name="HCR400_12" FT /average_identity="66.8 %" FT /score="120" FT misc_feature 728..766 FT /note="transcriptional regulator" FT /citation=[2] FT polyA_signal 760..765 //