ID ACTG_3UT SEQUENCES: 6; ALIGNED BASES: 1126. AC CU00169; DT 22-AUG-1996 (CREATED) DT 22-AUG-1996 (LAST UPDATE) XX DE CYTOSKELETAL GAMMA-ACTIN, 3'UTR. AG 335 MYRS (AMNIOTA/AMPHIBIA). LO 3'UTR (STOP CODON TO POLYADENYLATION SITE). CC -!- PROTEIN FUNCTION :ACTINS ARE HIGHLY CONSERVED PROTEINS THAT ARE CC INVOLVED IN VARIOUS TYPES OF CELL MOTILITY AND ARE UBIQUITOUSLY CC EXPRESSED IN ALL EUKARYOTIC CELLS. XX CC -!- PROTEIN SUBCELLULAR LOCATION: CYTOPLASMIC. XX CC -!- GENE EXPRESSION: WIDELY EXPRESSED. XX CC -!- mRNA SUBCELLULAR LOCATION: SPECIFIC SUBCELLULAR LOCATION IN CC MYOBLASTS [1]. XX CC -!- BEST SCORE: 336. XX CC THE 3'UTR OF THE GAMMA-ACTIN GENE INFLUENCES THE IMPACT OF THE CC GENE ON MYOBLAST MORPHOLOGY [2]. CC CC BETA AND GAMMA CYTOPLASMIC ACTINS ARE FOUND IN ALL NONMUSCLE CELLS AND CC DIFFER BY ONLY FOUR AMINO ACIDS AT THE AMINO-TERMINAL REGION. BOTH CC GENES ARE REGULATED TEMPORALLY AND SPATIALLY, THOUGH NO DIFFERENCES IN CC PROTEIN FUNCTION HAVE BEEN DESCRIBED. THE TWO MRNAS HAVE DIFFERENT CC SUBCELLULAR LOCALIZATION IN MYOBLASTS [1]. THE TWO GENES HAVE TOTALLY CC DISTINCT BUT HIGHLY CONSERVED 3'UTRS (SEE CU00100). IT HAS BEEN PROPOSED CC THAT THE FUNCTIONAL SIGNIFICANCE OF THE DIFFERENT ACTIN ISOFORMS MAY CC INVOLVE THE PROPERTIES OF THEIR NONCODING REGIONS IN ADDITION TO THE CC DIFFERENCES IN PROTEIN SEQUENCE [2]. XX RN [1] RX MEDLINE; 93352696. RA Hill M.A., Gunning P.; RT "Beta and gamma actin mRNAs are differentially located within myoblasts"; RL J. Cell Biol. 122:825-32(1993). XX RN [2] RX MEDLINE; 93209992. RA Lloyd C., Gunning P.; RT "Noncoding regions of the gamma-actin gene influence the impact of the RT gene on myoblast morphology"; RL J. Cell Biol. 121:73-82(1993). XX SN [1] SI ACTG_3UT.1.ANSAN SL 791. OS ANSER ANSER (WESTERN GRAYLAG GOOSE). TX SAUROPSIDA (BIRDS AND REPTILES). DR EMBL; M26111. mRNA; gamma-actin XX SN [2] SI ACTG_3UT.1.XENLA SL 865. OS XENOPUS LAEVIS (AFRICAN CLAWED FROG). TX AMPHIBIA. DR EMBL; M24769. mRNA; cytoskeletal actin type-5 XX SN [3] SI ACTG_3UT.1.RATBL SL 729. OS RATTUS RATTUS (BLACK RAT). TX MAMMALIA. DR EMBL; X52815. mRNA; cytoplasmic-gamma isoform of actin XX SN [4] SI ACTG_3UT.1.HUMAN SL 996. OS HOMO SAPIENS (HUMAN). TX MAMMALIA. DR EMBL; M19283. gene; cytoskeletal gamma-actin DR EMBL; X04098. mRNA; DR EMBL; M16247. mRNA; XX SN [5] SI ACTG_3UT.1.MOUSE SL 670. OS MUS MUSCULUS (MOUSE). TX MAMMALIA. DR EMBL; X13055. mRNA; cytoplasmic gamma-actin DR EMBL; L21996. gene; DR EMBL; M21495. mRNA; XX SN [6] SI ACTG_3UT.1.BOVIN SL 428. OS BOS TAURUS (BOVINE). TX MAMMALIA. DR EMBL; K00623. mRNA; gamma-actin XX FT 3'UTR 1..846 FT HCR310 1..150 FT /name="HCR310_1" FT /average_identity="74.7 %" FT /score="337" FT HCR335 1..112 FT /name="HCR335_2" FT /average_identity="75.7 %" FT /score="281" FT HCR310 193..250 FT /name="HCR310_3" FT /average_identity="62.4 %" FT /score="105" FT HCR310 636..714 FT /name="HCR310_4" FT /average_identity="72.7 %" FT /score="213" FT HCR335 651..714 FT /name="HCR335_5" FT /average_identity="71.9 %" FT /score="168" FT HCR310 796..818 FT /name="HCR310_6" FT /average_identity="78.3 %" FT /score="70" FT polyA_signal 829..834 //