Genetic Variation In Human Populations

Description

This data set gives genotypes variation of 1066 individuals belonging to 52 predefined populations, for 404 microsatellite markers.

Usage

data(hdpg)

Format

hdpg is a list of 3 components.

tab

is a data frame with the genotypes of 1066 individuals encoded with 6 characters (individuals in row, locus in column), for example ‘123098’ for a heterozygote carrying alleles ‘123’ and ‘098’, ‘123123’ for a homozygote carrying two alleles ‘123’ and, ‘000000’ for a not classified locus (missing data).

ind

is a a data frame with 4 columns containing information about the 1066 individuals: hdpg$ind$id containing the Diversity Panel identification number of each individual, and three factors hdpg$ind$sex, hdpg$ind$population and hdpg$ind$region containing the names of the 52 populations belonging to 7 major geographic regions (see details).

locus

is a dataframe containing four columns: hdpg$locus$marknames a vector of names of the microsatellite markers, hdpg$locus$allbyloc a vector containing the number of alleles by loci, hdpg$locus$chromosome a factor defining a number for one chromosome and, hdpg$locus$maposition indicating the position of the locus in the chromosome.

Details

The rows of hdpg$pop are the names of the 52 populations belonging to the geographic regions contained in the rows of hdpg$region. The chosen regions are: America, Asia, Europe, Middle East North Africa, Oceania, Subsaharan AFRICA.

The 52 populations are: Adygei, Balochi, Bantu, Basque, Bedouin, Bergamo, Biaka Pygmies, Brahui, Burusho, Cambodian, Columbian, Dai, Daur, Druze, French, Han, Hazara, Hezhen, Japanese, Kalash, Karitiana, Lahu, Makrani, Mandenka, Maya, Mbuti Pygmies, Melanesian, Miaozu, Mongola, Mozabite, Naxi, NewGuinea, Nilote, Orcadian, Oroqen, Palestinian, Pathan, Pima, Russian, San, Sardinian, She, Sindhi, Surui, Tu, Tujia, Tuscan, Uygur, Xibo, Yakut, Yizu, Yoruba.

hdpg$freq is a data frame with 52 rows, corresponding to the 52 populations described above, and 4992 microsatellite markers.

Source

Extract of data prepared by the Human Diversity Panel Genotypes (invalid http://research.marshfieldclinic.org/genetics/Freq/FreqInfo.htm)

prepared by Hinda Haned, from data used in: Noah A. Rosenberg, Jonatahan K. Pritchard, James L. Weber, Howard M. Cabb, Kenneth K. Kidds, Lev A. Zhivotovsky, Marcus W. Feldman (2002) Genetic Structure of human Populations Science, 298, 2381–2385.

Lev A. Zhivotovsky, Noah Rosenberg, and Marcus W. Feldman (2003). Features of Evolution and Expansion of Modern Humans, Inferred from Genomewide Microsatellite Markers Am. J. Hum. Genet, 72, 1171–1186.

Examples

## Not run: 
  data(hdpg)
  freq <- char2genet(hdpg$tab, hdpg$ind$population)
  vec <- apply(freq$tab, 2, function(c) mean(c, na.rm = TRUE))
  for (j in 1:4492){
      freq$tab[is.na(freq$tab[,j]),j] = vec[j]}
  pcatot <- dudi.pca(freq$tab, center = TRUE, scale = FALSE, scannf = FALSE, nf = 4)


if(adegraphicsLoaded()) {
  s.label(pcatot$li, xax = 1, yax = 2, psub.text = "1-2", lab = freq$pop.names)
} else {
  s.label(pcatot$li, xax = 1, yax = 2, sub = "1-2", lab = freq$pop.names)
}
## End(Not run)