(data stored in SCRATCH zone)

SWISSPROT: A0A0F6BIB8_GEOS0

ID   A0A0F6BIB8_GEOS0        Unreviewed;       381 AA.
AC   A0A0F6BIB8;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   16-JAN-2019, entry version 24.
DE   RecName: Full=Signal transduction histidine-protein kinase/phosphatase DegS {ECO:0000256|PIRNR:PIRNR003169};
DE            EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR003169};
DE            EC=3.1.3.- {ECO:0000256|PIRNR:PIRNR003169};
GN   OrderedLocusNames=GY4MC1_0324 {ECO:0000313|EMBL:ADP73169.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73169.1, ECO:0000313|Proteomes:UP000002034};
RN   [1] {ECO:0000313|EMBL:ADP73169.1, ECO:0000313|Proteomes:UP000002034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73169.1,
RC   ECO:0000313|Proteomes:UP000002034};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA   Ovchinnikova G., Brumm P., Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the two-component regulatory system DegS/DegU,
CC       which plays an important role in the transition growth phase.
CC       {ECO:0000256|PIRNR:PIRNR003169}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|PIRNR:PIRNR003169};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR003169}.
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DR   EMBL; CP002293; ADP73169.1; -; Genomic_DNA.
DR   RefSeq; WP_013399951.1; NC_014650.1.
DR   EnsemblBacteria; ADP73169; ADP73169; GY4MC1_0324.
DR   KEGG; gmc:GY4MC1_0324; -.
DR   KO; K07777; -.
DR   OMA; IIFDLRP; -.
DR   OrthoDB; 1755994at2; -.
DR   BioCyc; GSP581103:G1GOQ-369-MONOMER; -.
DR   Proteomes; UP000002034; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR008595; DegS.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   InterPro; IPR016381; Sig_transdc_His_kinase_DegS.
DR   Pfam; PF05384; DegS; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   PIRSF; PIRSF003169; STHK_DegS; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; A0A0F6BIB8.
DR   SWISS-2DPAGE; A0A0F6BIB8.
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR003169};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002034};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR003169};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR003169};
KW   Kinase {ECO:0000256|PIRNR:PIRNR003169, ECO:0000313|EMBL:ADP73169.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR003169};
KW   Protein phosphatase {ECO:0000256|PIRNR:PIRNR003169};
KW   Transferase {ECO:0000256|PIRNR:PIRNR003169};
KW   Two-component regulatory system {ECO:0000256|PIRNR:PIRNR003169}.
FT   DOMAIN      188    381       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   COILED       48     68       {ECO:0000256|SAM:Coils}.
FT   COILED      105    139       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   381 AA;  44204 MW;  C513EE08A9FD57C2 CRC64;
     MSANKNLNVK ELDKIVEKMI DTVQHSKDEI FRIGEQSRQE YEWMVKELAE VKAAIHRTIE
     EADKLEVQTR RSRQRLSEVS RNFASHSENE IREAYEKAHE LHMELAMVRE REKQLRLRRD
     ELERRLIGLK ETIERADHLV GQVTVVLNYL TSDFRQVGEF IEGARRKQEF GLKIIEAQEE
     ERKRLSREIH DGPAQTLAHV IIRSDLMEKV LKDRGIEAAI SEIRDFKKMV RSALYEVRRI
     IYDLRPMALD DLGLVPTLRK YLQTVEDYSK GIDISFVHIG KEMRLPPRLE VAVFRLVQEA
     VQNALKHAEA TKIEVKTEMC SGQLLVMVKD DGKGFDTTMK KENAFGLMGM KERVDLLEGT
     LTIRSKIGAG TTIFIRIPLN I
//

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