(data stored in SCRATCH zone)

SWISSPROT: A0A0F6BII5_GEOS0

ID   A0A0F6BII5_GEOS0        Unreviewed;       393 AA.
AC   A0A0F6BII5;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   08-MAY-2019, entry version 23.
DE   RecName: Full=ATP phosphoribosyltransferase regulatory subunit {ECO:0000256|HAMAP-Rule:MF_00125, ECO:0000256|SAAS:SAAS01178711};
GN   Name=hisZ {ECO:0000256|HAMAP-Rule:MF_00125};
GN   OrderedLocusNames=GY4MC1_0395 {ECO:0000313|EMBL:ADP73236.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73236.1, ECO:0000313|Proteomes:UP000002034};
RN   [1] {ECO:0000313|EMBL:ADP73236.1, ECO:0000313|Proteomes:UP000002034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73236.1,
RC   ECO:0000313|Proteomes:UP000002034};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA   Ovchinnikova G., Brumm P., Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the first step of histidine biosynthesis.
CC       May allow the feedback regulation of ATP phosphoribosyltransferase
CC       activity by histidine. {ECO:0000256|HAMAP-Rule:MF_00125,
CC       ECO:0000256|SAAS:SAAS01178718}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC       {ECO:0000256|HAMAP-Rule:MF_00125, ECO:0000256|SAAS:SAAS01178741}.
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00125}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00125,
CC       ECO:0000256|SAAS:SAAS01178737}.
CC   -!- MISCELLANEOUS: This function is generally fulfilled by the C-
CC       terminal part of HisG, which is missing in some bacteria such as
CC       this one. {ECO:0000256|HAMAP-Rule:MF_00125}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. HisZ subfamily. {ECO:0000256|HAMAP-Rule:MF_00125,
CC       ECO:0000256|SAAS:SAAS01178726}.
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DR   EMBL; CP002293; ADP73236.1; -; Genomic_DNA.
DR   RefSeq; WP_003248063.1; NC_014650.1.
DR   EnsemblBacteria; ADP73236; ADP73236; GY4MC1_0395.
DR   KEGG; gmc:GY4MC1_0395; -.
DR   KO; K02502; -.
DR   OMA; GYELVMP; -.
DR   OrthoDB; 1236894at2; -.
DR   BioCyc; GSP581103:G1GOQ-440-MONOMER; -.
DR   UniPathway; UPA00031; UER00006.
DR   Proteomes; UP000002034; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   HAMAP; MF_00125; HisZ; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR004517; HisZ.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   TIGRFAMs; TIGR00443; hisZ_biosyn_reg; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0F6BII5.
DR   SWISS-2DPAGE; A0A0F6BII5.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00125,
KW   ECO:0000256|SAAS:SAAS01178732};
KW   Aminoacyl-tRNA synthetase {ECO:0000313|EMBL:ADP73236.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002034};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00125,
KW   ECO:0000256|SAAS:SAAS01178748};
KW   Histidine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00125,
KW   ECO:0000256|SAAS:SAAS01178715}; Ligase {ECO:0000313|EMBL:ADP73236.1}.
FT   DOMAIN       22    325       AA_TRNA_LIGASE_II. {ECO:0000259|PROSITE:
FT                                PS50862}.
SQ   SEQUENCE   393 AA;  44314 MW;  99DC03456D3F4EFA CRC64;
     MTKKLFMFEK PLGMRDTLPF LYEIKKRVRQ AMVREIETWG YELIETPTLE YYETVGAASA
     IDDHQLFKLL DQQGHTLVLR PDMTAPIARL AASRLYQDGN PLRLAYNANV FRAQQREGGR
     PAEFEQIGVE CIGDGTVAAD AEVISVMIAA LKQTGLRNFT VAIGHIGYVN ALFLEILGNE
     ERASVLRRFL YEKNYVGYRE HVKSLPLSSI DQKRLLQLLH LRGNDKTMEN ARELVHSEEG
     KRAVDELCEL ASALQLYGVD GAVKIDMSLV SHMSYYTGIL FEVYAEHVGF PIGNGGRYDE
     LLEKFSRKAP ATGFGVRVDR LIEALGESEA EAAIECIVFS QERFAEALEL ARTKRREGKR
     VVLQHILGIR DIDAYSKKYQ PITYLLGSGG KEE
//

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