(data stored in SCRATCH zone)

SWISSPROT: A0A0F6BIS6_GEOS0

ID   A0A0F6BIS6_GEOS0        Unreviewed;       390 AA.
AC   A0A0F6BIS6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   16-JAN-2019, entry version 22.
DE   SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:ADP73327.1};
DE            EC=2.3.1.16 {ECO:0000313|EMBL:ADP73327.1};
GN   OrderedLocusNames=GY4MC1_0495 {ECO:0000313|EMBL:ADP73327.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73327.1, ECO:0000313|Proteomes:UP000002034};
RN   [1] {ECO:0000313|EMBL:ADP73327.1, ECO:0000313|Proteomes:UP000002034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73327.1,
RC   ECO:0000313|Proteomes:UP000002034};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA   Ovchinnikova G., Brumm P., Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP002293; ADP73327.1; -; Genomic_DNA.
DR   RefSeq; WP_013400063.1; NC_014650.1.
DR   EnsemblBacteria; ADP73327; ADP73327; GY4MC1_0495.
DR   GeneID; 29236854; -.
DR   KEGG; gmc:GY4MC1_0495; -.
DR   KO; K00632; -.
DR   OMA; MTAFPEP; -.
DR   OrthoDB; 330994at2; -.
DR   BioCyc; GSP581103:G1GOQ-546-MONOMER; -.
DR   Proteomes; UP000002034; Chromosome.
DR   GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0F6BIS6.
DR   SWISS-2DPAGE; A0A0F6BIS6.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ADP73327.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002034};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ADP73327.1}.
FT   DOMAIN        5    259       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      268    388       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     90     90       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    346    346       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    376    376       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   390 AA;  41432 MW;  9111123807577458 CRC64;
     MREAVIVAGA RTPVGKAKKG TLAHVRPDDL GALVVRETLK RAGNYEGNID DLIIGCAMPE
     AEQGLNIARN IGALAGLPYT VPAITINRYC SSGLQAIAYA AERIMLGHSD TIIAGGVESM
     SLVPMMGHVI RPNAKLAEEA PQYYMSMGHT AEQVAMKYGV SREDQDAFAV RSHQRAAKAI
     REGKFKDEIV PVEVTVRKVE NNKLVEKTIL FEEDEGVRPD TNMETLAKLH PAFSVNGTVT
     AGNASQMSDG AAAVMVMDRE KAESLGLKLL GKFRSFAVAG VPPEVMGIGP VAAIPKALKL
     AGLELSDIGL IELNEAFASQ AIQVIRELGL DEEKVNVNGG AIALGHPLGC TGAKLTLSLL
     YEMRRRNVQF GIVTMCIGGG MGAAGVFELI
//

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