(data stored in SCRATCH zone)

SWISSPROT: A0A0H2ZKY2_PSEAB

ID   A0A0H2ZKY2_PSEAB        Unreviewed;       290 AA.
AC   A0A0H2ZKY2;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-JUL-2017, entry version 14.
DE   RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
DE            EC=1.5.1.20 {ECO:0000256|RuleBase:RU003862};
GN   Name=metF {ECO:0000313|EMBL:ABJ15397.1};
GN   OrderedLocusNames=PA14_05590 {ECO:0000313|EMBL:ABJ15397.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963 {ECO:0000313|EMBL:ABJ15397.1, ECO:0000313|Proteomes:UP000000653};
RN   [1] {ECO:0000313|EMBL:ABJ15397.1, ECO:0000313|Proteomes:UP000000653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14 {ECO:0000313|EMBL:ABJ15397.1,
RC   ECO:0000313|Proteomes:UP000000653};
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- CATALYTIC ACTIVITY: 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-
CC       methylenetetrahydrofolate + NAD(P)H.
CC       {ECO:0000256|RuleBase:RU003862}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU003862};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|RuleBase:RU003862}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC       family. {ECO:0000256|RuleBase:RU003862}.
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DR   EMBL; CP000438; ABJ15397.1; -; Genomic_DNA.
DR   RefSeq; WP_003118821.1; NC_008463.1.
DR   ProteinModelPortal; A0A0H2ZKY2; -.
DR   SMR; A0A0H2ZKY2; -.
DR   EnsemblBacteria; ABJ15397; ABJ15397; PA14_05590.
DR   KEGG; pau:PA14_05590; -.
DR   KO; K00297; -.
DR   OMA; FIRAETG; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003171; Mehydrof_redctse.
DR   InterPro; IPR004620; MTHF_reductase_bac.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; SSF51730; 1.
DR   TIGRFAMs; TIGR00676; fadh2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2ZKY2.
DR   SWISS-2DPAGE; A0A0H2ZKY2.
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004255};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000653};
KW   FAD {ECO:0000256|RuleBase:RU003862};
KW   Flavoprotein {ECO:0000256|RuleBase:RU003862};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003862}.
SQ   SEQUENCE   290 AA;  32229 MW;  39D26F9443D896DA CRC64;
     MVASKEPIMS QSERRFSFEF FPAKTEAGHE KLLATARNLA GYKPDFFSCT YGAGGSTRDR
     TLSTVLQLDG EVKVPTAPHL SCVGDSKAEL RELLGRYREA GIRRIVALRG DLPSGMGMAS
     GELRYANELV DFIRTETGDH FHIEVAAYPE VHPQARSFED DLANFVRKVK AGASSAITQY
     FFNADAYFYF VERVAKLGVD IPVVPGIMPI TNYSKLARFS DACGAELPRW IRKQLEAYGD
     DSRSIQAFGE QVISEMCERL LEGGAPGLHF YTLNQADPSL AIWKNLQLPR
//

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