(data stored in SCRATCH zone)

SWISSPROT: A0A0H2ZL12_PSEAB

ID   A0A0H2ZL12_PSEAB        Unreviewed;       316 AA.
AC   A0A0H2ZL12;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   30-AUG-2017, entry version 10.
DE   RecName: Full=Virginiamycin B lyase {ECO:0000256|PIRNR:PIRNR026412};
DE            EC=4.2.99.- {ECO:0000256|PIRNR:PIRNR026412};
DE   AltName: Full=Streptogramin B lyase {ECO:0000256|PIRNR:PIRNR026412};
GN   OrderedLocusNames=PA14_06130 {ECO:0000313|EMBL:ABJ15433.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963 {ECO:0000313|EMBL:ABJ15433.1, ECO:0000313|Proteomes:UP000000653};
RN   [1] {ECO:0000313|EMBL:ABJ15433.1, ECO:0000313|Proteomes:UP000000653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14 {ECO:0000313|EMBL:ABJ15433.1,
RC   ECO:0000313|Proteomes:UP000000653};
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Inactivates the type B streptogramin antibiotics by
CC       linearizing the lactone ring at the ester linkage, generating a
CC       free phenylglycine carboxylate and converting the threonyl moiety
CC       into 2-amino-butenoic acid. {ECO:0000256|PIRNR:PIRNR026412}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRNR:PIRNR026412};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|PIRNR:PIRNR026412}.
CC   -!- SIMILARITY: Belongs to the Vgb family.
CC       {ECO:0000256|PIRNR:PIRNR026412}.
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DR   EMBL; CP000438; ABJ15433.1; -; Genomic_DNA.
DR   RefSeq; WP_003111755.1; NC_008463.1.
DR   EnsemblBacteria; ABJ15433; ABJ15433; PA14_06130.
DR   KEGG; pau:PA14_06130; -.
DR   KO; K18235; -.
DR   OMA; CWFTEWG; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0016835; F:carbon-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 3.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011217; Streptogrm_lyase.
DR   PIRSF; PIRSF026412; Streptogrm_lyase; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2ZL12.
DR   SWISS-2DPAGE; A0A0H2ZL12.
KW   Antibiotic resistance {ECO:0000256|PIRNR:PIRNR026412};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000653};
KW   Lyase {ECO:0000256|PIRNR:PIRNR026412, ECO:0000313|EMBL:ABJ15433.1};
KW   Magnesium {ECO:0000256|PIRNR:PIRNR026412};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR026412};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    316       Virginiamycin B lyase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5002603500.
SQ   SEQUENCE   316 AA;  33560 MW;  F4F91B926EE4D7FA CRC64;
     MRHLPYPLLG LLLALSSTGA ALAGEQYYPL DKGSAPYAVA PSAQGAVWYG ADGGHSLGRL
     DPTSGESVQV PLGEGARPRA IVSDESGNAW VLDSGLNAIL RIGGERLGSE RFPLPAKAAP
     AGLESAVFDD DGRLWFTGSR GFHGRLDPAR RLVEVWPSPQ GKAANGICVT PDGEVWYAQD
     DALVHVDPLD GSAERLPAPE GTKALRGIGA DSIGRLWASD SGGARLYRYD PSDASWQSWP
     LPDSQARPDS LRVDAMDRVW LHDAASGALL RFDSEQATFR VLPSDRPAPG NALLGGRPGE
     TWSAEPAADR LRVVRD
//

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