(data stored in SCRATCH zone)

SWISSPROT: A0A0H3JCD7_ECO57

ID   A0A0H3JCD7_ECO57        Unreviewed;       289 AA.
AC   A0A0H3JCD7;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-JUL-2017, entry version 17.
DE   SubName: Full=Putative reductase {ECO:0000313|EMBL:BAB33761.1};
GN   OrderedLocusNames=ECs0338 {ECO:0000313|EMBL:BAB33761.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|EMBL:BAB33761.1, ECO:0000313|Proteomes:UP000000558};
RN   [1] {ECO:0000313|EMBL:BAB33761.1, ECO:0000313|Proteomes:UP000000558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC   {ECO:0000313|Proteomes:UP000000558};
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
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DR   EMBL; BA000007; BAB33761.1; -; Genomic_DNA.
DR   RefSeq; NP_308365.2; NC_002695.1.
DR   ProteinModelPortal; A0A0H3JCD7; -.
DR   STRING; 155864.Z0377; -.
DR   EnsemblBacteria; BAB33761; BAB33761; BAB33761.
DR   GeneID; 914437; -.
DR   KEGG; ecs:ECs0338; -.
DR   PATRIC; fig|386585.9.peg.432; -.
DR   Proteomes; UP000000558; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
DR   PRODOM; A0A0H3JCD7.
DR   SWISS-2DPAGE; A0A0H3JCD7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000558}.
FT   DOMAIN       16    262       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   ACT_SITE     49     49       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000097-1}.
FT   BINDING     112    112       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000097-2}.
FT   SITE         78     78       Lowers pKa of active site Tyr.
FT                                {ECO:0000256|PIRSR:PIRSR000097-3}.
SQ   SEQUENCE   289 AA;  32703 MW;  89C22DF57A5286F0 CRC64;
     MEFSVLSNNL KMPMMGFGVF QVTDKNVCKQ SVLNAIRTGY RLIDTAAVYG NEDAVGEAVR
     EAISEGLCTR EELFITSKLW VQDMLNQDTA AAGIEASLKK SGLEYFDLYL LHQAMRDYFS
     AWRALEDAYE EGKLKAIGVS NFYPHVLANF CETVRVKPMV NQVELHPYFA QPEALATMKY
     YNVQPEAWAP LGGGRHKPFE NNLLQSIADA HQKSISQVIL RWNIQRGVVV IPKSTHQQRI
     EENFAIWDFS LTEKEMAQIS SLDLGYVGES VKHFNPEFVR GCLAVKIHD
//

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