(data stored in SCRATCH zone)

SWISSPROT: A0A143ZZY8_PLAF7

ID   A0A143ZZY8_PLAF7        Unreviewed;      2269 AA.
AC   A0A143ZZY8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   08-MAY-2019, entry version 16.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CZT62778.1};
GN   ORFNames=PF3D7_0833500 {ECO:0000313|EMBL:CZT62778.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT62778.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CZT62778.1; -; Genomic_DNA.
DR   RefSeq; XP_002808728.1; XM_002808682.1.
DR   EnsemblProtists; CZT62778; CZT62778; PF3D7_0833500.
DR   GeneID; 9221932; -.
DR   KEGG; pfa:PF3D7_0833500; -.
DR   KO; K13850; -.
DR   OMA; FRATCID; -.
DR   PhylomeDB; A0A143ZZY8; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR008602; Duffy-antigen_binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 2.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 2.
PE   4: Predicted;
DR   PRODOM; A0A143ZZY8.
DR   SWISS-2DPAGE; A0A143ZZY8.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN       17     53       NTS. {ECO:0000259|Pfam:PF15447}.
FT   DOMAIN      663    824       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1464   1512       CIDR1_gamma. {ECO:0000259|Pfam:PF18562}.
FT   DOMAIN     1532   1677       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1797   2269       ATS. {ECO:0000259|Pfam:PF15445}.
FT   COILED      203    230       {ECO:0000256|SAM:Coils}.
FT   COILED      381    405       {ECO:0000256|SAM:Coils}.
FT   COILED     1661   1681       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2269 AA;  255775 MW;  1A5BA86A5DCA7EA3 CRC64;
     MAQGGRGGQV GGDDYSDAKH LLDSIGKKVH DEIVKKDAKT YIGELAGLLS QASIFGGETV
     AFSEPCGLIK NESQKLAALG DPCGSASEKR FSKERVDEYD KKKIKCSNSE GACAPYRRLH
     VCDKNMVKMD TNNDSKAKHD LLLDVCLAAK YEGESLKTYR AQYDEQYPSS VSTFTMCTML
     ARSFADIGDI VRGRDLYRGN RKKNETKTER EKLDDKLKEI FENIRKENNS KLKSLTDDQI
     REYWWTANRN DVWKAITCSA DKGNTYFRAT CIDLNESPSM ARDKCRCKDK SFTKETDQVP
     TYFDYVPQFL RWFEEWAEDF CRKKKKYVDI VKTYCRNETK GKYCSLNGYD CTKTKPAIGR
     LRMGNQCTKC FFACYPYEKW IDKKKEEFLK QKQKYEKEME KYTNEASGST GGRAKRSVST
     TNYDGYESKF YKILKDKYKD EGLNKFLEKL SNEDVCTKVD DEGGKIRFEK VNSGGTARSG
     GTSGTSSTSG DSGTNDINNK TFYRSKYCQP CPLCGMKRTK NGGNKWEEKS GGNCKSGKLY
     RPKGGKDVTP IRILKSGENH DDIEEKLNAF CQAQNGTGGV ANGSGSGTSD SQKLYQEWKC
     YQLEELTKVV QDGVEDEDDE DDEVYDKEVE GAGGLCILKK KKEKSEGKSQ NDPDEIQKTF
     HNFFYYWVAH MLKDSIHWRT KKLDKCLQNG KKKCGKKICN GDCDCFKRWV EQKRKEWDPI
     KKQFSKQKGI PFGCYFTTLE GVLQLEFLNE NTDEDAENNV SAEEAKEIQH LRQMLKQAGV
     AIGLDALGGC GTGGDSDNEK ETLMDKFLEE EEQFAEKCIK KCQETQKQPT GDGVADTSPD
     PSRDTNVDPE QEEEEEEDDS EEQDATVNGP EDGGGEATQQ PQGPSEKKEE VKVCETVKTA
     LGGNLDEACN QKYGLPQRHW GWKCIPSGSG STATREGEGS SDGGAKDGVG VNGGVLQRAR
     RGTPGEKTAT SSDSGAICVP PRRRRLYVTP LTRLAGGDKD TQASVSPQVV GETPQVSTPA
     LTSPPPSDPR ADVDLVKAFV ESAAVETFFL WDRYKKEWEH RNKKPQDGLL LFGESTASDH
     MAALSHTGGP QQQPGSVSDD PQSKLQKSGE IPTDFLRQMF YTLGDYRDIC IGGDRDIVGD
     TIVSNTEGGT PTKISEKIEQ ILSKQSGTHP PTPPGPPQTS VEKTTRESWW NAHAPSIWKG
     MICALTYKDG EEGKSPQVDT TVQKELLDKD GKPLNPQYQY TNAKLEEKNS GAKQNRNPTA
     PSDNKPTTLV DFISRPPYFR YLEEWGENFC KERKKRLKQI KVECKVDQDN DKNGKKCSGY
     GEDCHDNVFN NNYTTFPDFY CPDCGKYCSS YRKWIERKGK EFIKQKNAYK EQKTNFQTQS
     ETAKEFLQKL GSCKNNNRNE NAEDNNKIFE DNGDTFEPAK DCKPCSQFRV KSEKCNCRSS
     GKGNTCNDKN SIDVNDIGDG GNSTVLEMRV SDDSKSGSGF DGLGECKEAH IFKGIRKDVW
     TCEKVCGYNV CKPIKVDGKE NGENQIIIIR ALFKRWLEYF LEDYNKIRKK LKPCKKNGEG
     SPCIKDCDKI CECVTKWIEK KRTEWTNIKK HYLEKKHEKG DDGMTSLVKN FLEDLQDRPE
     FQNAIKPCND LNAFEKSCGL HGAEISQKKE GEDYDLVLCL LKKLEEKAKK CKEDHSSGEQ
     TEKECQEYPP LPDEEYENED ENEKTNIQPK FCPKQQTPPK QEDEDGCVPA EAPKEVVPEK
     KVPSDPPPAP APAAPPSTPA APKHPRGGEE KKAKPSLPNP PTVFDNPHVK TALVTSTLAW
     SVGIGFAAFT YFYLKKKTKS PVDLLRVLDI HKGDYDIPTK LSPNRYIPYT SGKYRGKTYI
     YLEGDSGTDS GYTDHYSDIT SSSESEYEEL DINDIYVPGS PKYKTLIEVV LEPSGNNTTA
     SGKNTTASGK TQSGNNTTAS GKNTPSDTQN DIQNDGIPSN KFSDNEWNTL KDDFISNMLQ
     NEPNTEQNML GYNVDNNTHP TMSRDNMEEK PFITSIHDRD LYTGEEYNYN VNMSTNNVDI
     PMSDKNGNYT GIDLINDTLS GNHNVDIYDE LLKRKENELF GTNNPKRTST YSVAKNTNSD
     PILNQINLFH TWLDRHRDMC EQWDTNNKKE ELLDKLKEEW ENETHSGNTH PSDSNKTLNT
     DVSIQIHMDD PKTTNEFTYV DSNPNQVDDT YVDTYPNNSS MDTILEDLEK YKEPYYDVQD
     DIYYDVNDDH DTSTVDSNNM DVPSKVQIEM DVNTKLVKEK YPIADVWDI
//

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