(data stored in SCRATCH zone)

SWISSPROT: DNAA_AERHH

ID   DNAA_AERHH              Reviewed;         456 AA.
AC   A0KEC3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=AHA_0001;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM
OS   1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240;
RX   PubMed=16980456; DOI=10.1128/jb.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000462; ABK36302.1; -; Genomic_DNA.
DR   RefSeq; WP_005307141.1; NC_008570.1.
DR   RefSeq; YP_854527.1; NC_008570.1.
DR   SMR; A0KEC3; -.
DR   STRING; 380703.AHA_0001; -.
DR   PRIDE; A0KEC3; -.
DR   EnsemblBacteria; ABK36302; ABK36302; AHA_0001.
DR   GeneID; 4490513; -.
DR   KEGG; aha:AHA_0001; -.
DR   PATRIC; fig|380703.7.peg.2; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   BioCyc; AHYD380703:G1G7B-1-MONOMER; -.
DR   PRO; PR:A0KEC3; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KEC3.
DR   SWISS-2DPAGE; A0KEC3.
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..456
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_1000048599"
FT   NP_BIND         161..168
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   456 AA;  51865 MW;  ECFA28DC67A0CD8D CRC64;
     MTASLWQQCL NRLQDELPSA EFSMWIRPLQ AELSDNTLTL YAPNRFVLDW VRDKYLIRVN
     GIINELCGVD GPTLRFDIGN RPHPVAVARA PARGADPVNN SQKSWESKAE AKPEPNHKSN
     TNVNYTFENF VEGKSNQLAR AAARQVADNP GGAYNPLFLY GGTGLGKTHL LHAVGNAIKE
     RKQDAKVIYM HSERFVQDMV KALQNNAIEE FKRYYRSVDA LLIDDIQFFA NKERSQEEFF
     HTFNALLEGN QQIILTSDRY PKEINGVEDR LKSRFGWGLT VAIEPPELET RVAILMRKAD
     ENQIHLPDEV AFFIAKRLRS NVRELEGALN RVIANANFTG RAINIDFVRE ALRDLLALQE
     KLVTIDNIQK TVAEYYKIKL ADLLSKRRSR SVARPRQLAM ALAKELTNHS LPEIGDAFGG
     RDHTTVLHAC RKIEQLKEES HDIKEDYSNL IRTLSS
//

If you have problems or comments...

PBIL Back to PBIL home page