(data stored in SCRATCH zone)

SWISSPROT: A0KEC4_AERHH

ID   A0KEC4_AERHH            Unreviewed;       284 AA.
AC   A0KEC4;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 99.
DE   RecName: Full=Guanylate kinase {ECO:0000256|HAMAP-Rule:MF_00328, ECO:0000256|SAAS:SAAS00356201};
DE            EC=2.7.4.8 {ECO:0000256|HAMAP-Rule:MF_00328, ECO:0000256|SAAS:SAAS00356190};
DE   AltName: Full=GMP kinase {ECO:0000256|HAMAP-Rule:MF_00328};
GN   Name=gmk {ECO:0000256|HAMAP-Rule:MF_00328};
GN   OrderedLocusNames=AHA_0041 {ECO:0000313|EMBL:ABK36516.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK36516.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK36516.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC       {ECO:0000256|HAMAP-Rule:MF_00328, ECO:0000256|SAAS:SAAS00036649}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:456216; EC=2.7.4.8; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00328, ECO:0000256|SAAS:SAAS01120090};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00328}.
CC   -!- SIMILARITY: Belongs to the guanylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00328, ECO:0000256|SAAS:SAAS00548802}.
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DR   EMBL; CP000462; ABK36516.1; -; Genomic_DNA.
DR   RefSeq; WP_011704080.1; NC_008570.1.
DR   RefSeq; YP_854566.1; NC_008570.1.
DR   STRING; 380703.AHA_0041; -.
DR   EnsemblBacteria; ABK36516; ABK36516; AHA_0041.
DR   GeneID; 4490261; -.
DR   KEGG; aha:AHA_0041; -.
DR   PATRIC; fig|380703.7.peg.36; -.
DR   eggNOG; ENOG4108UHA; Bacteria.
DR   eggNOG; COG0194; LUCA.
DR   HOGENOM; HOG000037638; -.
DR   KO; K00942; -.
DR   OMA; AGNYYGT; -.
DR   BioCyc; AHYD380703:G1G7B-41-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004385; F:guanylate kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00328; Guanylate_kinase; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR017665; Guanylate_kinase.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03263; guanyl_kin; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KEC4.
DR   SWISS-2DPAGE; A0KEC4.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00328,
KW   ECO:0000256|SAAS:SAAS00238200}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00328};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00328,
KW   ECO:0000256|SAAS:SAAS00434181, ECO:0000313|EMBL:ABK36516.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00328,
KW   ECO:0000256|SAAS:SAAS00434271};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00328,
KW   ECO:0000256|SAAS:SAAS00434142, ECO:0000313|EMBL:ABK36516.1}.
FT   DOMAIN       81    261       Guanylate kinase-like.
FT                                {ECO:0000259|PROSITE:PS50052}.
FT   NP_BIND      88     95       ATP. {ECO:0000256|HAMAP-Rule:MF_00328}.
FT   COILED      260    284       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   284 AA;  32287 MW;  F2CFB86E56BA21A2 CRC64;
     MAADVGDAPA ASYEYFDRLE YDSGRFFIRH LLLKFAAFTS LSIQEFSAFR IWLSPFRAQD
     GGLCYNQNTV SLKGTDMAQQ GTLYIISSPS GAGKSSLLNA LLTQHNSAGK MQLSVSHTTR
     ATRPGEEHGV HYHFVKVEEF KALIERGDFL EWAEVFGNYY GTSRAAIEAC LAQGIDVFLD
     IDWQGARQIR EQMPTKSIFI LPPSREELER RLIGRGQDSA EVIKGRMEKA IAEMVHYDEY
     DYVIINEDFE QALFQLRAVI ECQRLELRQQ QQAQQNLLQQ LLAE
//

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