(data stored in SCRATCH zone)

SWISSPROT: A0KEG3_AERHH

ID   A0KEG3_AERHH            Unreviewed;       339 AA.
AC   A0KEG3;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=Delta-aminolevulinic acid dehydratase {ECO:0000256|RuleBase:RU000515};
DE            EC=4.2.1.24 {ECO:0000256|RuleBase:RU000515};
GN   Name=hemB {ECO:0000313|EMBL:ABK39315.1};
GN   OrderedLocusNames=AHA_0091 {ECO:0000313|EMBL:ABK39315.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK39315.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK39315.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen;
CC         Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24;
CC         Evidence={ECO:0000256|RuleBase:RU000515};
CC   -!- SUBUNIT: Homooctamer. {ECO:0000256|RuleBase:RU000515}.
CC   -!- SIMILARITY: Belongs to the ALAD family.
CC       {ECO:0000256|RuleBase:RU004161}.
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DR   EMBL; CP000462; ABK39315.1; -; Genomic_DNA.
DR   RefSeq; WP_011704123.1; NC_008570.1.
DR   RefSeq; YP_854613.1; NC_008570.1.
DR   STRING; 380703.AHA_0091; -.
DR   EnsemblBacteria; ABK39315; ABK39315; AHA_0091.
DR   GeneID; 4490986; -.
DR   KEGG; aha:AHA_0091; -.
DR   PATRIC; fig|380703.7.peg.82; -.
DR   eggNOG; ENOG4105D52; Bacteria.
DR   eggNOG; COG0113; LUCA.
DR   HOGENOM; HOG000020323; -.
DR   KO; K01698; -.
DR   OMA; YQMDYAN; -.
DR   BioCyc; AHYD380703:G1G7B-91-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004655; F:porphobilinogen synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR001731; ALAD.
DR   InterPro; IPR030656; ALAD_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   PANTHER; PTHR11458; PTHR11458; 1.
DR   Pfam; PF00490; ALAD; 1.
DR   PIRSF; PIRSF001415; Porphbilin_synth; 1.
DR   PRINTS; PR00144; DALDHYDRTASE.
DR   SMART; SM01004; ALAD; 1.
DR   PROSITE; PS00169; D_ALA_DEHYDRATASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KEG3.
DR   SWISS-2DPAGE; A0KEG3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Lyase {ECO:0000256|RuleBase:RU000515, ECO:0000313|EMBL:ABK39315.1};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Porphyrin biosynthesis {ECO:0000256|RuleBase:RU000515};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT   ACT_SITE    204    204       Schiff-base intermediate with substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001415-1}.
FT   ACT_SITE    259    259       Schiff-base intermediate with substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001415-1}.
FT   METAL       244    244       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR001415-5}.
SQ   SEQUENCE   339 AA;  37127 MW;  6F605F3D8A8C2E3A CRC64;
     MATTLPGAFP GRRLRRVRKH DFSRRLVREN VLTANDLIYP VFVLEGENRR EAVTSMPGVD
     RLSIDLLLKE AAELVALGVP AIALFPVTPL EQKSLLAEEA YNPDGLAQRA TRALKVSFPE
     LGVITDVALD PFTTHGQDGI IDDEGYVLND ITTEILVKQA LSHAAAGVDI VAPSDMMDGR
     IGAIRAALEE NGFINTQIMA YSAKYASCYY GPFRDAVGSA GNLGKSNKAT YQMDPANSNE
     ALHEVALDIK EGADSVMVKP GMPYLDVIRQ VKDQFGVPTF AYQVSGEYAM HMAAIQNGWL
     KEKESIMESL LCFKRAGADG ILTYFAKRAA QWLQEDARR
//

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