(data stored in SCRATCH zone)

SWISSPROT: A0KEK8_AERHH

ID   A0KEK8_AERHH            Unreviewed;       471 AA.
AC   A0KEK8;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 89.
DE   SubName: Full=Signal transduction histidine kinase {ECO:0000313|EMBL:ABK38358.1};
GN   OrderedLocusNames=AHA_0136 {ECO:0000313|EMBL:ABK38358.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK38358.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK38358.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP000462; ABK38358.1; -; Genomic_DNA.
DR   RefSeq; WP_011704162.1; NC_008570.1.
DR   RefSeq; YP_854673.1; NC_008570.1.
DR   STRING; 380703.AHA_0136; -.
DR   EnsemblBacteria; ABK38358; ABK38358; AHA_0136.
DR   GeneID; 4487516; -.
DR   KEGG; aha:AHA_0136; -.
DR   PATRIC; fig|380703.7.peg.129; -.
DR   eggNOG; ENOG4105E0F; Bacteria.
DR   eggNOG; ENOG410XTWD; LUCA.
DR   HOGENOM; HOG000218775; -.
DR   OMA; EWLYIAS; -.
DR   BioCyc; AHYD380703:G1G7B-136-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; A0KEK8.
DR   SWISS-2DPAGE; A0KEK8.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:ABK38358.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM    200    218       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      217    269       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      277    471       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   COILED      295    322       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   471 AA;  53632 MW;  2240F61A171B8A7E CRC64;
     MPRSLLSRML LLLLLAILLS QTILTGIWMQ QIQKRELEGM LSTTRNLALS AASTVNFFKS
     LPLQYRHIAL DQLRNMGGSR FFVSLNEEEI HISAIPDSER KTLVLKEVQG VLTRKLSDAM
     AIKVDFSRPE ELHVFNNDTL LADLPSSWAR YTLSLEPINP PVLVTQIEIE PGEWLYLAAL
     LPAPYMTLDD TVMPSNQVRF IALMTVFLCF FTFLLVRWQT RPLRRLAKAA VNLGKDIDQP
     SLKEEGASEI VAATRAFNIM QHRIRRYIDD RERLFSSISH DLKTPITRLR LRVELLDDEQ
     QIAKFNKDLD ELELMVKGAL QTVKDTDIHE NIEQLDIDAM LEQMAEAMNL HDERLTIEGH
     CKQPYRGKPL ALKRCIGNLV DNGIKYGQRV RIIIMDDEEM LILFIMDEGP GLPEDQFERI
     FEPYYRLSTD LAGTGLGLGI ARNIAHAHGG DLVLENRPQG GLQATLSLPR Q
//

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