(data stored in SCRATCH zone)

SWISSPROT: A0KET2_AERHH

ID   A0KET2_AERHH            Unreviewed;       723 AA.
AC   A0KET2;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 91.
DE   RecName: Full=DNA helicase {ECO:0000256|SAAS:SAAS00413339};
DE            EC=3.6.4.12 {ECO:0000256|SAAS:SAAS00413339};
GN   Name=uvrD {ECO:0000313|EMBL:ABK37514.1};
GN   OrderedLocusNames=AHA_0220 {ECO:0000313|EMBL:ABK37514.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK37514.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK37514.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00709641}.
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DR   EMBL; CP000462; ABK37514.1; -; Genomic_DNA.
DR   RefSeq; WP_011704228.1; NC_008570.1.
DR   RefSeq; YP_854747.1; NC_008570.1.
DR   STRING; 380703.AHA_0220; -.
DR   EnsemblBacteria; ABK37514; ABK37514; AHA_0220.
DR   GeneID; 4487729; -.
DR   KEGG; aha:AHA_0220; -.
DR   PATRIC; fig|380703.7.peg.207; -.
DR   eggNOG; ENOG4105C4R; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   HOGENOM; HOG000033016; -.
DR   KO; K03657; -.
DR   OMA; APIQTFH; -.
DR   BioCyc; AHYD380703:G1G7B-221-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR005753; DNA_helicase_ATP-dep_UvrD.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01075; uvrD; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KET2.
DR   SWISS-2DPAGE; A0KET2.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:ABK37514.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062,
KW   ECO:0000313|EMBL:ABK37514.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT   DOMAIN        8    286       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      287    564       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
SQ   SEQUENCE   723 AA;  81963 MW;  07A579744A623941 CRC64;
     MDVSTLLDGL NDKQRDAVAA PRCNLLVLAG AGSGKTRVLV HRIAWLMQVE RCSPFSIIAV
     TFTNKAAAEM RGRVEKVIGD GVRGMWIGTF HGIAHRLLRA HHLDAGLPQD FQILDSDDQY
     RLIRRVLKAL NLDEKHWAPR AVMGYINGKK DEGLRPGDID LYGDPVTRTY QQIYKTYQET
     CDRSGLVDFA ELLLRAHELW LNKPHILEHY RDRFQNILVD EFQDTNGIQY AWLRMLAGDT
     GKVMIVGDDD QSIYGWRGAK IENIQRFLTD YQGAETIRLE QNYRSTANIL KAANCVIANN
     AERLGKELWT EGAEGEPISL YAAFNEVDEA RFVVGRLKDW KEKGGLLADC AILYRSNAQS
     RVLEEALMQD AMPYRIYGGL RFFERQEIKD AMAYLRLINN RGDDASFERV VNTPTRGIGD
     RTLEILRNNA RDQGQNLWQS AKALLGDKVL TGRAGNAVRG FVDLIDALEE QVSLLPLHQQ
     ADIAIQHSGL KAMYLAEKGE KSQARVENLD ELVTACRQYQ RPDELEDMSD LSAFLAHAAL
     ESGENQADEY ADAVQLMTLH SAKGLEFPLV LLVGVEEGMF PSQQSTEESG RLEEERRLCY
     VGMTRAMEKL YICYAESRRI YGREMFHKPS RFIREMPAEC LEEIRLRTQV SRPTQYGRFS
     QNEVQQSFDA SGIKLGQRVL HPKFGEGIVL NFEGVGQQSR VQIQFDDVGA KWLVTAYARL
     ETL
//

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