(data stored in SCRATCH zone)

SWISSPROT: A0KFI3_AERHH

ID   A0KFI3_AERHH            Unreviewed;       325 AA.
AC   A0KFI3;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 97.
DE   RecName: Full=Tyrosine recombinase XerC {ECO:0000256|HAMAP-Rule:MF_01808, ECO:0000256|SAAS:SAAS00055375};
GN   Name=xerC {ECO:0000256|HAMAP-Rule:MF_01808,
GN   ECO:0000313|EMBL:ABK38032.1};
GN   OrderedLocusNames=AHA_0476 {ECO:0000313|EMBL:ABK38032.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK38032.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK38032.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by
CC       catalyzing the cutting and rejoining of the recombining DNA
CC       molecules. The XerC-XerD complex is essential to convert dimers of
CC       the bacterial chromosome into monomers to permit their segregation
CC       at cell division. It also contributes to the segregational
CC       stability of plasmids. {ECO:0000256|HAMAP-Rule:MF_01808}.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP-
CC       Rule:MF_01808, ECO:0000256|SAAS:SAAS00608017}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808,
CC       ECO:0000256|SAAS:SAAS00019473}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01808,
CC       ECO:0000256|SAAS:SAAS00608022}.
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DR   EMBL; CP000462; ABK38032.1; -; Genomic_DNA.
DR   RefSeq; WP_011704449.1; NC_008570.1.
DR   RefSeq; YP_855009.1; NC_008570.1.
DR   STRING; 380703.AHA_0476; -.
DR   EnsemblBacteria; ABK38032; ABK38032; AHA_0476.
DR   GeneID; 4488894; -.
DR   KEGG; aha:AHA_0476; -.
DR   PATRIC; fig|380703.7.peg.469; -.
DR   eggNOG; ENOG4108IYS; Bacteria.
DR   eggNOG; COG4973; LUCA.
DR   HOGENOM; HOG000045294; -.
DR   KO; K03733; -.
DR   OMA; FASHMLE; -.
DR   BioCyc; AHYD380703:G1G7B-477-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR011931; Recomb_XerC.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   TIGRFAMs; TIGR02224; recomb_XerC; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KFI3.
DR   SWISS-2DPAGE; A0KFI3.
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608023};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608024};
KW   Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608018};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00094312};
KW   DNA integration {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00298355};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00019433};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00424103};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT   DOMAIN       27    110       Integrase_SAM-like_N. {ECO:0000259|Pfam:
FT                                PF02899}.
FT   DOMAIN      132    301       Phage_integrase. {ECO:0000259|Pfam:
FT                                PF00589}.
FT   ACT_SITE    168    168       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    192    192       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    261    261       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    264    264       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    287    287       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    296    296       O-(3'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01808}.
SQ   SEQUENCE   325 AA;  36449 MW;  6306D38C3BE90969 CRC64;
     MAKTPARSPA KAPPAAEPLP AALADELAGF IEYLRVERQL SPHTRSNYQA HLEAMTAELV
     KLGVDDWARL EASQVRSLVT RMHKAGLAPR SLATKVSALR SFCDWQVRQG RLVANPARGI
     VTPKQGRPLP KNLDVDEMYQ LLNITDEQDP LAVRDRAIME LMYSSGLRLA ELVGLNLADV
     KLDERQLRVT GKGSRERVLP VGRMAVEWLH KWLKLRPLLA GDELEALFVS KRKQRLSARS
     VQERLDGWGN KQALNAHVHP HKLRHSFATH MLESSGDLRA VQELLGHADL STTQIYTHLD
     FQHLAKVYDS AHPRAKRDPA TPDDE
//

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