(data stored in SCRATCH zone)

SWISSPROT: A0LEY8_SYNFM

ID   A0LEY8_SYNFM            Unreviewed;       488 AA.
AC   A0LEY8;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 75.
DE   SubName: Full=23S rRNA (Uracil-5-)-methyltransferase RumA {ECO:0000313|EMBL:ABK15990.1};
DE            EC=2.1.1.- {ECO:0000313|EMBL:ABK15990.1};
GN   OrderedLocusNames=Sfum_0289 {ECO:0000313|EMBL:ABK15990.1};
OS   Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Syntrophobacter.
OX   NCBI_TaxID=335543 {ECO:0000313|EMBL:ABK15990.1, ECO:0000313|Proteomes:UP000001784};
RN   [1] {ECO:0000313|EMBL:ABK15990.1, ECO:0000313|Proteomes:UP000001784}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10017 / MPOB {ECO:0000313|Proteomes:UP000001784};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA   Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA   McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J.,
RA   Sieber J., Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT   "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. RNA M5U methyltransferase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01024,
CC       ECO:0000256|SAAS:SAAS00561307}.
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DR   EMBL; CP000478; ABK15990.1; -; Genomic_DNA.
DR   STRING; 335543.Sfum_0289; -.
DR   EnsemblBacteria; ABK15990; ABK15990; Sfum_0289.
DR   KEGG; sfu:Sfum_0289; -.
DR   eggNOG; ENOG4105BZT; Bacteria.
DR   eggNOG; COG2265; LUCA.
DR   HOGENOM; HOG000029870; -.
DR   KO; K03215; -.
DR   OMA; FYAGDMK; -.
DR   Proteomes; UP000001784; Chromosome.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   InterPro; IPR030390; MeTrfase_TrmA_AS.
DR   InterPro; IPR030391; MeTrfase_TrmA_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   PANTHER; PTHR11061; PTHR11061; 1.
DR   Pfam; PF01938; TRAM; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01230; TRMA_1; 1.
DR   PROSITE; PS01231; TRMA_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0LEY8.
DR   SWISS-2DPAGE; A0LEY8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001784};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01024,
KW   ECO:0000256|SAAS:SAAS00234999, ECO:0000313|EMBL:ABK15990.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001784};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01024,
KW   ECO:0000256|SAAS:SAAS00235009};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01024,
KW   ECO:0000256|SAAS:SAAS00506843, ECO:0000313|EMBL:ABK15990.1}.
FT   DOMAIN       17     75       TRAM. {ECO:0000259|PROSITE:PS50926}.
FT   ACT_SITE    445    445       {ECO:0000256|PROSITE-ProRule:PRU10015}.
FT   ACT_SITE    445    445       Nucleophile. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01024}.
FT   BINDING     317    317       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01024}.
FT   BINDING     346    346       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01024}.
FT   BINDING     367    367       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01024}.
FT   BINDING     418    418       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01024}.
SQ   SEQUENCE   488 AA;  54811 MW;  8CF6DFA63CE1ACF7 CRC64;
     MWGGRHGSKD RLPTMDDLKK GREYELLVEK LVFGGKALAR VEGLVVFMDH AVPGQRVRAL
     ITRKKRQYCE ARVVEVLSQS EAHTEPVCPH FGVCGGCQWQ DIAYEEQLKW KRVQVADSLE
     HLAGAQGVKI EAAVPSDRLI HYRNKMEFTF SDRRWLTPEE IDAAGMRDAY TFTLGLHVRS
     WFDKVFNVED CLLESAEAVE IVKETRDWCR GSGVPAYGIK SQRGFWRFLV IREGKRTGQT
     LLHLVTSDQP EHEAAVNTLT RHLVSRFPHI TTVVHSVSRK KAQVAFGDQS RVVAGPGVIE
     ERLGGLRFRI SAESFFQTNP FSAEKLYDEV SRLAAFQGTE TVWDLYCGTG SIALSVAPRV
     ARVVGFEVVD QAIEDACVNA RLNGIENARF ISGDLKERIN HARGPGSGEH HPDIVITDPP
     RAGMHPQVVG ALLEMGPGRI IYVSCNPATL ARDLAFFTER YEIGTVRPFD LFPHTPHIEC
     VVRMDRKR
//

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