(data stored in SCRATCH zone)

SWISSPROT: A0LF77_SYNFM

ID   A0LF77_SYNFM            Unreviewed;       432 AA.
AC   A0LF77;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=Phenylacetate-coenzyme A ligase {ECO:0000256|PIRNR:PIRNR006444};
DE            EC=6.2.1.30 {ECO:0000256|PIRNR:PIRNR006444};
DE   AltName: Full=Phenylacetyl-CoA ligase {ECO:0000256|PIRNR:PIRNR006444};
GN   OrderedLocusNames=Sfum_0379 {ECO:0000313|EMBL:ABK16079.1};
OS   Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Syntrophobacter.
OX   NCBI_TaxID=335543 {ECO:0000313|EMBL:ABK16079.1, ECO:0000313|Proteomes:UP000001784};
RN   [1] {ECO:0000313|EMBL:ABK16079.1, ECO:0000313|Proteomes:UP000001784}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10017 / MPOB {ECO:0000313|Proteomes:UP000001784};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA   Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA   McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J.,
RA   Sieber J., Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT   "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the activation of phenylacetic acid (PA) to
CC       phenylacetyl-CoA (PA-CoA). {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-phenylacetate + ATP + CoA = AMP + diphosphate +
CC         phenylacetyl-CoA; Xref=Rhea:RHEA:20956, ChEBI:CHEBI:18401,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57390, ChEBI:CHEBI:456215; EC=6.2.1.30;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006444};
CC   -!- PATHWAY: Aromatic compound metabolism; phenylacetate degradation.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- SIMILARITY: Belongs to the phenylacetyl-CoA ligase family.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
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DR   EMBL; CP000478; ABK16079.1; -; Genomic_DNA.
DR   RefSeq; WP_011697252.1; NC_008554.1.
DR   STRING; 335543.Sfum_0379; -.
DR   EnsemblBacteria; ABK16079; ABK16079; Sfum_0379.
DR   KEGG; sfu:Sfum_0379; -.
DR   eggNOG; ENOG4105DZS; Bacteria.
DR   eggNOG; COG1541; LUCA.
DR   HOGENOM; HOG000197614; -.
DR   KO; K01912; -.
DR   OMA; IQITPGY; -.
DR   OrthoDB; 839891at2; -.
DR   BioCyc; SFUM335543:G1G7I-384-MONOMER; -.
DR   UniPathway; UPA00930; -.
DR   Proteomes; UP000001784; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0047475; F:phenylacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010124; P:phenylacetate catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR028154; AMP-dep_Lig_C.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; AMP-dep_Synthh-like_sf.
DR   InterPro; IPR011880; PA_CoA_ligase.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF14535; AMP-binding_C_2; 1.
DR   PIRSF; PIRSF006444; PaaK; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0LF77.
DR   SWISS-2DPAGE; A0LF77.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001784};
KW   Ligase {ECO:0000256|PIRNR:PIRNR006444, ECO:0000313|EMBL:ABK16079.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR006444};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001784}.
FT   DOMAIN       83    285       AMP-binding. {ECO:0000259|Pfam:PF00501}.
FT   DOMAIN      335    428       AMP-binding_C_2. {ECO:0000259|Pfam:
FT                                PF14535}.
SQ   SEQUENCE   432 AA;  48640 MW;  84C66CBDD1BFBA50 CRC64;
     MSVSFMPVRA SREDLHALQL QGLQWTVSHA YRNSPFYRAK LDAAGVGPDA VRSLDDLSRL
     PLTTASDLKD GYPFPLRSVP FEKIVRIHAS SGTTGKRKVL CYSQKDIDDW ACMFARCYEM
     ARLTREDRVQ IAVGYGLWTA GVGFQLGCER FGAMAVPIGP ANTEIHCQML LDMQSTVFCA
     TASMALLIAE EIERRGIQKK IALKKFIFGA ERHSAGMRRR IREITGVNEL FDIPGLTELY
     GPGTGLECPA HEGVHYWADY YILEILNPET LEPVAPGEVG EMVVTTLRKE AAPLIRYRTR
     DLTRLIPGDC PCGNPLPRHD HLLGRSDDMF IFRAVNIYPG QIDHVLSQIS GIGSEYQVHL
     YRREDGRDVM LVKVEQVGSD SPDADRKLAE TVAAEVRRQI MVRCQVEILE YGTLPRTERK
     SRRVFDHRTV ED
//

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