(data stored in SCRATCH zone)

SWISSPROT: A1SCQ1_NOCSJ

ID   A1SCQ1_NOCSJ            Unreviewed;       543 AA.
AC   A1SCQ1;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   SubName: Full=Thiamine pyrophosphate enzyme domain protein TPP-binding protein {ECO:0000313|EMBL:ABL79586.1};
GN   OrderedLocusNames=Noca_0036 {ECO:0000313|EMBL:ABL79586.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL79586.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL79586.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C.,
RA   Copeland A., Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A.,
RA   Hammon N.M., Han S., Hauser L.J., Israni S., Kim E., Kyrpides N.,
RA   Land M.L., Lapidus A., Larimer F.W., Lucas S., Pitluck S.,
RA   Richardson P., Schmutz J., Tapia R., Thompson S., Tice H.N.,
RA   Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing
RT   actinomycete Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP000509; ABL79586.1; -; Genomic_DNA.
DR   RefSeq; WP_011753537.1; NC_008699.1.
DR   STRING; 196162.Noca_0036; -.
DR   EnsemblBacteria; ABL79586; ABL79586; Noca_0036.
DR   KEGG; nca:Noca_0036; -.
DR   eggNOG; ENOG4105C7K; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000258445; -.
DR   KO; K01652; -.
DR   OMA; ATWVHRF; -.
DR   OrthoDB; 391134at2; -.
DR   BioCyc; NSP196162:GH4V-39-MONOMER; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SCQ1.
DR   SWISS-2DPAGE; A1SCQ1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        3    170       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      190    322       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      378    523       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   543 AA;  57121 MW;  61B1B19185B6A863 CRC64;
     MPHVGDAMID AIASAGVRRL YTVPGESFLE VLDAADRHPA LRQFSTRHES GASFMADADA
     KTSGVPAVAM ATRGPGAANL SIGVHTAHQD GTPMLVLIGD VETPRIFRGA FQEVDLPAFY
     RPITKAAMTA RRGDRLPEMV TDALRIAVSG RPGPVMISLP ADLLAEEFTG PAPAPLAPVA
     PAGCPPETVR RLRSTLERAQ RPVVIAGAGV RHATDRLVAL CEAYGLGVYA AMRRQDVFPN
     DHPLYLGHLG VSPAPGTVDA LREADVVLIL GAALDQMTTQ QFTLPAASAH RIHVDADPLT
     LGAGLPVDEA VVAEPRELIE ALLAEPPTAP HRAWDAAHRR FLESTCAPPR TPARGCDPGA
     VIEAMKRAWP ADTIVTSDAG NFSGFLHQYW RFTTPRSQAA PINGAMGYAV PGAVGAKAAS
     PDRHVLGVVG DGGFLMTGSE VETAVRYGLP LTIVVLRNGL YGTIAMHQAQ EMGRLSAVDI
     GDVDLAAYGR SLGAEGITVE EPGQLDEAMR TAATSDAVTV VDVVTDPDLI TASGRLSEMF
     QTS
//

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