(data stored in SCRATCH zone)

SWISSPROT: A1SCZ6_NOCSJ

ID   A1SCZ6_NOCSJ            Unreviewed;       504 AA.
AC   A1SCZ6;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 63.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ABL79681.1};
GN   OrderedLocusNames=Noca_0136 {ECO:0000313|EMBL:ABL79681.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL79681.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL79681.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C.,
RA   Copeland A., Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A.,
RA   Hammon N.M., Han S., Hauser L.J., Israni S., Kim E., Kyrpides N.,
RA   Land M.L., Lapidus A., Larimer F.W., Lucas S., Pitluck S.,
RA   Richardson P., Schmutz J., Tapia R., Thompson S., Tice H.N.,
RA   Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing
RT   actinomycete Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP000509; ABL79681.1; -; Genomic_DNA.
DR   STRING; 196162.Noca_0136; -.
DR   EnsemblBacteria; ABL79681; ABL79681; Noca_0136.
DR   KEGG; nca:Noca_0136; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239123; -.
DR   OMA; TALFMEN; -.
DR   BioCyc; NSP196162:GH4V-135-MONOMER; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SCZ6.
DR   SWISS-2DPAGE; A1SCZ6.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     31     58       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     70     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    100    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    125    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    158    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    187    209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    221    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    256    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    327    348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    360    378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    384    411       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    423    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    466    488       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    492       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   504 AA;  52862 MW;  6DD983183F81D35F CRC64;
     MTETQDERTA PAPGRPVDAP DAPPEGLDRR VLMVAGVVVL GAIMSILDIT VVSVALQTFQ
     QEFDATSAEV AWTMTGYTLA LASVIPLTGW AADRFGTKRL YLLAVLLFTA GSVLCAAATS
     LEMLVSFRVL QGVGGGMLMP LGMTILTRAA GPERVGRVMA VLGIPMLLGP IFGPILGGAL
     IDSASWHWIF LINLPIGIAA LAYAAVVLPR DHVEPSETFD WLGMVLLSPG LAAFLYGVSS
     IPAAREEHGT LWTTEVVAPA LAGLLLIAAF VPWALNRRNL HPLVDLRLFG NGTMTAAVLS
     MSLFAIAFFG ASLLFPLYFQ WVRGEDALGA GLLLAPQGVG AMITMPIAGV LADRIGPGKI
     VLTGIAVITV GMGMFTQLDQ DTSYAYLLTA LFVMGLGMGA TMMPIMSAAL ATLREHTIAR
     GSTLMNIVQQ VAASIGTAVF AMLLTNGTID LDPSDPAGFV TGLADAFAHV FVVATVMVAL
     VLVPAFFLPR RKVAPADPTL VVGH
//

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