(data stored in SCRATCH zone)

SWISSPROT: A1SDH6_NOCSJ

ID   A1SDH6_NOCSJ            Unreviewed;       678 AA.
AC   A1SDH6;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 77.
DE   RecName: Full=DNA polymerase III subunit gamma/tau {ECO:0000256|RuleBase:RU364063};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU364063};
GN   Name=dnaX {ECO:0000256|RuleBase:RU364063};
GN   OrderedLocusNames=Noca_0317 {ECO:0000313|EMBL:ABL79861.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL79861.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL79861.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C.,
RA   Copeland A., Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A.,
RA   Hammon N.M., Han S., Hauser L.J., Israni S., Kim E., Kyrpides N.,
RA   Land M.L., Lapidus A., Larimer F.W., Lucas S., Pitluck S.,
RA   Richardson P., Schmutz J., Tapia R., Thompson S., Tice H.N.,
RA   Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing
RT   actinomycete Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria.
CC       This DNA polymerase also exhibits 3' to 5' exonuclease activity.
CC       {ECO:0000256|RuleBase:RU364063}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU364063};
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha,
CC       epsilon and theta chains) that associates with a tau subunit. This
CC       core dimerizes to form the POLIII' complex. PolIII' associates
CC       with the gamma complex (composed of gamma, delta, delta', psi and
CC       chi chains) and with the beta chain to form the complete DNA
CC       polymerase III complex. {ECO:0000256|RuleBase:RU364063}.
CC   -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC       {ECO:0000256|RuleBase:RU364063}.
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DR   EMBL; CP000509; ABL79861.1; -; Genomic_DNA.
DR   RefSeq; WP_011753812.1; NC_008699.1.
DR   STRING; 196162.Noca_0317; -.
DR   EnsemblBacteria; ABL79861; ABL79861; Noca_0317.
DR   KEGG; nca:Noca_0317; -.
DR   eggNOG; ENOG4107QMP; Bacteria.
DR   eggNOG; COG2812; LUCA.
DR   HOGENOM; HOG000083933; -.
DR   KO; K02343; -.
DR   OMA; DVMEMDA; -.
DR   OrthoDB; 556582at2; -.
DR   BioCyc; NSP196162:GH4V-321-MONOMER; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR022754; DNA_pol_III_gamma-3.
DR   InterPro; IPR012763; DNA_pol_III_sug/sutau.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF12169; DNA_pol3_gamma3; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02397; dnaX_nterm; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SDH6.
DR   SWISS-2DPAGE; A1SDH6.
KW   ATP-binding {ECO:0000256|RuleBase:RU364063};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   DNA replication {ECO:0000256|RuleBase:RU364063};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU364063};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU364063};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU364063,
KW   ECO:0000313|EMBL:ABL79861.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640};
KW   Transferase {ECO:0000256|RuleBase:RU364063,
KW   ECO:0000313|EMBL:ABL79861.1}.
FT   DOMAIN       38    182       AAA. {ECO:0000259|SMART:SM00382}.
SQ   SEQUENCE   678 AA;  71449 MW;  64A92935B1748D3C CRC64;
     MESPLALYRR YRPETFAEVI GQAHVTEPLR VALANNRVNH AYLFSGPRGC GKTTSARILA
     RALNCDQAPV ADPCGECESC RDLARGGPGS IDVIEIDAAS HGGVDDARDL REKAFFAPVR
     SKYKVYIIDE AHMVTTQGFN ALLKLVEEPP PHLRFIFATT EPDKVLPTIR SRTHHYPFRL
     IPPRLLSSYL SELCAKEGVA IDPAALPLVV RAGGGSARDT LSVLDQLLGG AGPAGVTHEL
     AAGLLGYTPD TLLDEVVDAF AAGDGAAVFR VVDKVVETGQ DPRRFTEDLL RRLRDLVIVA
     AVPDAPATGL IDVSEDQGER LVAQAARFGA AELSRAADIA ATGLTEMRGA TAPRLLLELL
     CARILLPGAD HATDGVLARL DRLEKRLTIT GVPTPTAAAP APPAQDRPTP PPARPAAPDP
     AAERPDPVAA PPPAAPPAPQ APPVSAPTAE PEPAAEPPMA EPPVAEQTSA EPAEPPPASA
     PAGAAGGLTL VDVRRLWPDI VDATKLRRRV AWMHLTQNCQ VVGVDGQTLT LGFTNAGARD
     SFVNGGCDEV LRQAAIDVVG ADWRIETIID PGARADVPVV TTPAVPAADP APAPEAGPPA
     EEAPQPRRTS DPESIAAARE AIQQTRAGDE PRPEGPDWAA ADADAHPDDL DADQQGMSTA
     ELLQRELGAQ MIEEIRHQ
//

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