(data stored in SCRATCH zone)

SWISSPROT: A1SDS5_NOCSJ

ID   A1SDS5_NOCSJ            Unreviewed;       143 AA.
AC   A1SDS5;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 78.
DE   RecName: Full=Ribonuclease H {ECO:0000256|SAAS:SAAS01082054};
DE            EC=3.1.26.4 {ECO:0000256|SAAS:SAAS01082054};
GN   OrderedLocusNames=Noca_0418 {ECO:0000313|EMBL:ABL79960.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL79960.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL79960.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C.,
RA   Copeland A., Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A.,
RA   Hammon N.M., Han S., Hauser L.J., Israni S., Kim E., Kyrpides N.,
RA   Land M.L., Lapidus A., Larimer F.W., Lucas S., Pitluck S.,
RA   Richardson P., Schmutz J., Tapia R., Thompson S., Tice H.N.,
RA   Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing
RT   actinomycete Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
CC   -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-
CC       DNA hybrids. {ECO:0000256|SAAS:SAAS01082064}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.;
CC         EC=3.1.26.4; Evidence={ECO:0000256|SAAS:SAAS01118375};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS01082055};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|SAAS:SAAS01082108}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS01082116}.
CC   -!- SIMILARITY: Belongs to the RNase H family.
CC       {ECO:0000256|SAAS:SAAS01082081}.
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DR   EMBL; CP000509; ABL79960.1; -; Genomic_DNA.
DR   RefSeq; WP_011753911.1; NC_008699.1.
DR   STRING; 196162.Noca_0418; -.
DR   EnsemblBacteria; ABL79960; ABL79960; Noca_0418.
DR   KEGG; nca:Noca_0418; -.
DR   eggNOG; ENOG4108UMW; Bacteria.
DR   eggNOG; COG0328; LUCA.
DR   HOGENOM; HOG000040465; -.
DR   KO; K03469; -.
DR   OMA; MQEIEIF; -.
DR   OrthoDB; 1953872at2; -.
DR   BioCyc; NSP196162:GH4V-422-MONOMER; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   CDD; cd09278; RNase_HI_prokaryote_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR022892; RNaseHI.
DR   Pfam; PF00075; RNase_H; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50879; RNASE_H; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SDS5.
DR   SWISS-2DPAGE; A1SDS5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS01082089};
KW   Endonuclease {ECO:0000256|SAAS:SAAS01082063};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01082115,
KW   ECO:0000313|EMBL:ABL79960.1};
KW   Magnesium {ECO:0000256|SAAS:SAAS01082062};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01082080};
KW   Nuclease {ECO:0000256|SAAS:SAAS01082100};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640}.
FT   DOMAIN        4    142       RNase H. {ECO:0000259|PROSITE:PS50879}.
SQ   SEQUENCE   143 AA;  15692 MW;  D53C073BB5FFAA6C CRC64;
     MPVPEGAREV FTDGACSGNP GPGGWAWALD TAVYASGREA PSTNQRMEIR AALEAVRSLD
     GPLLVVSDST YVVHCFRDLW WQGWLDRDWV SSARKPVANR DLWEPLVGLV QDRGDVAFAW
     VKGHSGHVMN DFVDRLAVAA TRA
//

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