(data stored in SCRATCH zone)

SWISSPROT: A1SE00_NOCSJ

ID   A1SE00_NOCSJ            Unreviewed;       225 AA.
AC   A1SE00;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000256|HAMAP-Rule:MF_01131};
GN   Name=rex {ECO:0000256|HAMAP-Rule:MF_01131};
GN   OrderedLocusNames=Noca_0493 {ECO:0000313|EMBL:ABL80035.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL80035.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL80035.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C.,
RA   Copeland A., Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A.,
RA   Hammon N.M., Han S., Hauser L.J., Israni S., Kim E., Kyrpides N.,
RA   Land M.L., Lapidus A., Larimer F.W., Lucas S., Pitluck S.,
RA   Richardson P., Schmutz J., Tapia R., Thompson S., Tice H.N.,
RA   Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing
RT   actinomycete Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
CC   -!- FUNCTION: Modulates transcription in response to changes in
CC       cellular NADH/NAD(+) redox state. {ECO:0000256|HAMAP-
CC       Rule:MF_01131, ECO:0000256|SAAS:SAAS00345902}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01131,
CC       ECO:0000256|SAAS:SAAS00345894}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01131,
CC       ECO:0000256|SAAS:SAAS00345872}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000256|HAMAP-Rule:MF_01131, ECO:0000256|SAAS:SAAS00541514}.
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DR   EMBL; CP000509; ABL80035.1; -; Genomic_DNA.
DR   STRING; 196162.Noca_0493; -.
DR   EnsemblBacteria; ABL80035; ABL80035; Noca_0493.
DR   KEGG; nca:Noca_0493; -.
DR   eggNOG; ENOG4105FF6; Bacteria.
DR   eggNOG; COG2344; LUCA.
DR   HOGENOM; HOG000250064; -.
DR   KO; K01926; -.
DR   OMA; QILAFHE; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050662; F:coenzyme binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; PTHR35786; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SE00.
DR   SWISS-2DPAGE; A1SE00.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01131,
KW   ECO:0000256|SAAS:SAAS00345885};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01131,
KW   ECO:0000256|SAAS:SAAS00345893};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_01131, ECO:0000256|SAAS:SAAS00424161};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_01131,
KW   ECO:0000256|SAAS:SAAS00345859};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01131,
KW   ECO:0000256|SAAS:SAAS00424131};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01131,
KW   ECO:0000256|SAAS:SAAS00345910}.
FT   DOMAIN       91    192       CoA_binding. {ECO:0000259|SMART:SM00881}.
FT   DNA_BIND     28     67       H-T-H motif. {ECO:0000256|HAMAP-Rule:
FT                                MF_01131}.
FT   NP_BIND     102    107       NAD. {ECO:0000256|HAMAP-Rule:MF_01131}.
SQ   SEQUENCE   225 AA;  24247 MW;  1E8E79E2C40D1610 CRC64;
     METRSVSART SPESARDIPE ATVARLPVYL RALVTLSEQG TATCSSEELA VAAGVNSAKL
     RKDLSYLGSY GTRGVGYDVD YLRYQIAREI GVTQDWPVVI VGIGNLGQAL ANYSGFRSRG
     FRVVALLDAD PARHDQVVAG IEVRPFDHLE RIVRDHAVAI GVIATPAVAA QDVADRMVAY
     GITSILNFAP TVLTVPAEVD VRKVDLSIEL QILAYHEQRK GAVTA
//

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