(data stored in SCRATCH zone)

SWISSPROT: A1SE14_NOCSJ

ID   A1SE14_NOCSJ            Unreviewed;       297 AA.
AC   A1SE14;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   RecName: Full=1,4-dihydroxy-2-naphthoate octaprenyltransferase {ECO:0000256|HAMAP-Rule:MF_01937};
DE            Short=DHNA-octaprenyltransferase {ECO:0000256|HAMAP-Rule:MF_01937};
DE            EC=2.5.1.74 {ECO:0000256|HAMAP-Rule:MF_01937};
GN   Name=menA {ECO:0000256|HAMAP-Rule:MF_01937};
GN   OrderedLocusNames=Noca_0507 {ECO:0000313|EMBL:ABL80049.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL80049.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL80049.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C.,
RA   Copeland A., Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A.,
RA   Hammon N.M., Han S., Hauser L.J., Israni S., Kim E., Kyrpides N.,
RA   Land M.L., Lapidus A., Larimer F.W., Lucas S., Pitluck S.,
RA   Richardson P., Schmutz J., Tapia R., Thompson S., Tice H.N.,
RA   Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing
RT   actinomycete Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
CC   -!- FUNCTION: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to
CC       demethylmenaquinone (DMK). {ECO:0000256|HAMAP-Rule:MF_01937}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl
CC         diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate;
CC         Xref=Rhea:RHEA:26478, Rhea:RHEA-COMP:9563, Rhea:RHEA-COMP:9564,
CC         ChEBI:CHEBI:11173, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:55437, ChEBI:CHEBI:58914;
CC         EC=2.5.1.74; Evidence={ECO:0000256|HAMAP-Rule:MF_01937};
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis;
CC       menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.
CC       {ECO:0000256|HAMAP-Rule:MF_01937}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01937}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01937}.
CC   -!- SIMILARITY: Belongs to the MenA family. Type 1 subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01937}.
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DR   EMBL; CP000509; ABL80049.1; -; Genomic_DNA.
DR   STRING; 196162.Noca_0507; -.
DR   EnsemblBacteria; ABL80049; ABL80049; Noca_0507.
DR   KEGG; nca:Noca_0507; -.
DR   eggNOG; ENOG4105EIS; Bacteria.
DR   eggNOG; COG1575; LUCA.
DR   HOGENOM; HOG000028298; -.
DR   KO; K02548; -.
DR   OMA; PPMYSVA; -.
DR   UniPathway; UPA00079; UER00168.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0046428; F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01937; MenA_1; 1.
DR   InterPro; IPR004657; MenA.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR026046; UBIAD1.
DR   Pfam; PF01040; UbiA; 1.
DR   PIRSF; PIRSF005355; UBIAD1; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SE14.
DR   SWISS-2DPAGE; A1SE14.
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01937};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01937};
KW   Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_01937};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01937,
KW   ECO:0000313|EMBL:ABL80049.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01937};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01937}.
FT   TRANSMEM     43     64       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01937}.
FT   TRANSMEM     94    112       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01937}.
FT   TRANSMEM    118    135       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01937}.
FT   TRANSMEM    142    168       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01937}.
FT   TRANSMEM    174    193       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01937}.
FT   TRANSMEM    222    254       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01937}.
FT   TRANSMEM    274    295       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01937}.
SQ   SEQUENCE   297 AA;  30117 MW;  E636F06CADC1FF23 CRC64;
     MLESPVVATP DQWLAGARPR TLPAAVSPVL AGTGVAAYAD GLVWWKALLA LVVALALQVA
     VNYANDYSDG IRGTDADRVG PMRLVGSGAA RPAAVKRAAF LAFGVAAGAG LVLAATTAWW
     LVAVGLVSVL AAWFYTGGSK PYGYLGLGEV MVFVFFGLVA VLGTAYVQTE AWEWAALYAA
     VGVGTLACAI LVANNLRDIP TDAVAGKRTL AVVLGDRRTR SLFLLLVVLA AAAVVAVAAT
     TTWWALAGLG FLVLAGPAAR TVLGGAAGPG LIPVLQQTGL AELLWAVLVA AALVAGG
//

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