(data stored in ACNUC9543 zone)

SWISSPROT: A2A4N9_MOUSE

ID   A2A4N9_MOUSE            Unreviewed;      1174 AA.
AC   A2A4N9;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   08-MAY-2019, entry version 111.
DE   SubName: Full=ATP-dependent RNA helicase DHX8 {ECO:0000313|Ensembl:ENSMUSP00000119430};
DE   Flags: Fragment;
GN   Name=Dhx8 {ECO:0000313|Ensembl:ENSMUSP00000119430,
GN   ECO:0000313|MGI:MGI:1306823};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119430, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000119430, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119430,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000119430}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119430};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AL590994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL591436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; A2A4N9; -.
DR   jPOST; A2A4N9; -.
DR   PeptideAtlas; A2A4N9; -.
DR   PRIDE; A2A4N9; -.
DR   Ensembl; ENSMUST00000129741; ENSMUSP00000119430; ENSMUSG00000034931.
DR   MGI; MGI:1306823; Dhx8.
DR   eggNOG; ENOG410INHE; Eukaryota.
DR   eggNOG; KOG0922; Eukaryota.
DR   eggNOG; KOG0925; Eukaryota.
DR   eggNOG; COG1185; LUCA.
DR   eggNOG; COG1643; LUCA.
DR   GeneTree; ENSGT00940000155510; -.
DR   HOGENOM; HOG000175261; -.
DR   OMA; RIQKAIC; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000034931; Expressed in 232 organ(s), highest expression level in humerus cartilage element.
DR   ExpressionAtlas; A2A4N9; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd00079; HELICc; 1.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50126; S1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; A2A4N9.
DR   SWISS-2DPAGE; A2A4N9.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00444849};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00444804};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00444780};
KW   Proteomics identification {ECO:0000213|EPD:A2A4N9,
KW   ECO:0000213|MaxQB:A2A4N9, ECO:0000213|PeptideAtlas:A2A4N9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN      236    307       S1 motif. {ECO:0000259|PROSITE:PS50126}.
FT   DOMAIN      546    709       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      727    907       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   COILED      446    466       {ECO:0000256|SAM:Coils}.
FT   NON_TER    1174   1174       {ECO:0000313|Ensembl:ENSMUSP00000119430}.
SQ   SEQUENCE   1174 AA;  134360 MW;  8E8AF61D7159A81D CRC64;
     MAVAVAAAGV LMGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN
     TTFDTFKASL VKNGAEFTTM LDEEDVKVAV DVLKELEALM PSAAGQEKQR DPEHRDRTKK
     KKRSRSRDRD RDRDRDRDRD RDRDRDRDKD RERDRDRERD RERDRERDHK RRHRSRSRSH
     SRTRERTKGK SRYRSRSRSQ SPFKDRKDRE KYGERNLDRW RDKHVDRPPP EEPAIGDIYN
     GKVTSIMQFG CFVQLEGLRK RWEGLVHISE LRREGRVANV ADVVSKGQRV KVKVLSFTGT
     KTSLSMKDVD QETGEDLNPN RRRNLVGETN EETSMRNPDR PTHLSLVSAP EVEDDSLERK
     RLTRISDPEK WEIKQMIAAN VLSKEEFPDF DEETGILPKV DDEEDEDLEI ELVEEEPPFL
     RGHTKQSMDM SPIKIVKNPD GSLSQAAMMQ SALAKERREL KQAQREAEMD SIPMGLNKHW
     VDPLPDAEGR QIAANMRGIG MMPNDIPEWK KHAFGGNKAS YGKKTQMSIL EQRESLPIYK
     LKEQLVQAVH DNQILIVIGE TGSGKTTQIT QYLAEAGYTS RGKIGCTQPR RVAAMSVAKR
     VSEEFGCCLG QEVGYTIRFE DCTSPETVIK YMTDGMLLRE CLIDPDLTQY AIIMLDEAHE
     RTIHTDVLFG LLKKTVQKRQ DMKLIVTSAT LDAVKFSQYF YEAPIFTIPG RTYPVEILYT
     KEPETDYLDA SLITVMQIHL TEPPGDILVF LTGQEEIDTA CEILYERMKS LGPDVPELII
     LPVYSALPSE MQTRIFDPAP PGSRKVVIAT NIAETSLTID GIYYVVDPGF VKQKVYNSKT
     GIDQLVVTPI SQAQAKQRAG RAGRTGPGKC YRLYTERAYR DEMLTTNVPE IQRTNLASTV
     LSLKAMGIND LLSFDFMDAP PMETLITAME QLYTLGALDD EGLLTRLGRR MAEFPLEPML
     CKMLIMSVHL GCSEEMLTIV SMLSVQNVFY RPKDKQALAD QKKAKFHQTE GDHLTLLAVY
     NSWKNNKFSN PWCYENFIQA RSLRRAQDIR KQMLGIMDRH KLDVVSCGKS TVRVQKAICS
     GFFRNAAKKD PQEGYRTLID QQVVYIHPSS ALFNRQPEWV VYHELVLTTK EYMREVTTID
     PRWLVEFAPA FFKVSDPTKL SKQKKQQRLE PLYN
//

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