(data stored in ACNUC23405 zone)

SWISSPROT: A2CEW5_DANRE

ID   A2CEW5_DANRE            Unreviewed;       320 AA.
AC   A2CEW5;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   30-AUG-2017, entry version 82.
DE   SubName: Full=Motor neuron and pancreas homeobox 2b {ECO:0000313|Ensembl:ENSDARP00000040367};
GN   Name=mnx2b {ECO:0000313|Ensembl:ENSDARP00000040367,
GN   ECO:0000313|ZFIN:ZDB-GENE-040415-2};
GN   Synonyms=hlxb9lb {ECO:0000313|ZFIN:ZDB-GENE-040415-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000040367, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000040367, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000040367,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000040367}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000040367};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
CC       ProRule:PRU00108, ECO:0000256|RuleBase:RU000682,
CC       ECO:0000256|SAAS:SAAS00544279}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000040367}.
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DR   EMBL; CR762428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001009887.2; NM_001009887.2.
DR   UniGene; Dr.113407; -.
DR   ProteinModelPortal; A2CEW5; -.
DR   PaxDb; A2CEW5; -.
DR   Ensembl; ENSDART00000040368; ENSDARP00000040367; ENSDARG00000030350.
DR   GeneID; 406206; -.
DR   KEGG; dre:406206; -.
DR   CTD; 406206; -.
DR   ZFIN; ZDB-GENE-040415-2; mnx2b.
DR   eggNOG; KOG0489; Eukaryota.
DR   eggNOG; ENOG410ZTBY; LUCA.
DR   GeneTree; ENSGT00760000118940; -.
DR   HOGENOM; HOG000234345; -.
DR   HOVERGEN; HBG051910; -.
DR   KO; K08025; -.
DR   Proteomes; UP000000437; Chromosome 1.
DR   Bgee; ENSDARG00000030350; -.
DR   ExpressionAtlas; A2CEW5; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IGI:ZFIN.
DR   InterPro; IPR009057; Homeobox-like.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeobox; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
DR   PRODOM; A2CEW5.
DR   SWISS-2DPAGE; A2CEW5.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00022856};
KW   Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00022921};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00427283};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN      152    212       Homeobox DNA-binding.
FT                                {ECO:0000259|PROSITE:PS50071}.
FT   DNA_BIND    154    213       Homeobox. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00108}.
FT   COILED      246    273       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   320 AA;  35755 MW;  3D94A69722F5F0F1 CRC64;
     MEKSKNFRID ALLAEEPHRG SREVSPGLSS DSPTGSPVSC RRGDTPSPRG TPGAIHLQPG
     IIPKPGLLNL PHPGLTSIPG MYTTPMYPIS ALGGQHPALA YTGFTQLTQP YPEQLKAAAM
     AGSLPLEHWI RAGIMVPRLP DYTSAPQSGL MGKCRRPRTA FTSQQLLELE NQFKLNKYLS
     RPKRFEVATS LMLTETQVKI WFQNRRMKWK RSRKAKEQAA QVEVERQRGG TKPSGRDSRR
     APAAPSVEEQ EEEEEEEEEI DEDEEDEEDG QHKFINNSLS VSRSTDFLHH TAALYHPDSP
     FSEDDIEELH GGERKIRAGL
//

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