(data stored in SCRATCH zone)

SWISSPROT: A2Q7M8_ASPNC

ID   A2Q7M8_ASPNC            Unreviewed;       693 AA.
AC   A2Q7M8;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 68.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=An01g01290 {ECO:0000313|EMBL:CAK43501.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK43501.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|RuleBase:RU362003, ECO:0000256|SAAS:SAAS00711027}.
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DR   EMBL; AM269954; CAK43501.1; -; Genomic_DNA.
DR   PaxDb; A2Q7M8; -.
DR   EnsemblFungi; CAK43501; CAK43501; An01g01290.
DR   HOGENOM; HOG000220823; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0042300; F:beta-amyrin synthase activity; IEA:InterPro.
DR   GO; GO:0000250; F:lanosterol synthase activity; IEA:InterPro.
DR   GO; GO:0019746; P:hopanoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SUPFAM; SSF48239; SSF48239; 2.
DR   TIGRFAMs; TIGR01507; hopene_cyclase; 1.
DR   TIGRFAMs; TIGR01787; squalene_cyclas; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q7M8.
DR   SWISS-2DPAGE; A2Q7M8.
KW   Isomerase {ECO:0000256|RuleBase:RU362003, ECO:0000313|EMBL:CAK43501.1};
KW   Repeat {ECO:0000256|SAAS:SAAS00711039}.
FT   DOMAIN          26..319
FT                   /note="SQHop_cyclase_N"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          330..668
FT                   /note="SQHop_cyclase_C"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   693 AA;  77392 MW;  44E724DF5CD8D9EC CRC64;
     MAHQETMASE TSISLHTLAC DATKLAGTYA LRQVREDGHW YGEMKSNATI TAEYVFLAQA
     LGFSIEEDRD DLIKYFLSEQ NTDGSWSLAY DFPGDVSVTA EAYFALCLLG LDRSHPAMAS
     AREFTLSKGG IAKVRVFTRM FFACFGLFPW SAVPELPAEL ILLPAAAPMS IYQLASWARA
     TVVPMLVIRH HRPIYALPNG RSSSNEYLDE LWVDPTDKMV PYSPSLWSLW NDDLTAFGFT
     LADNILKALG GLRWFPSRKI ALRHCVAWIL ERQEPEGDIG GIFPPLHAAL FALALEGYGL
     ESSPVRRGID ALQNTYAWRD STGLRIQGCI SPILDTILMT IGLIDSSLPA ESPLVARSSR
     YLKAHQQLGN EGDWRVYNGN VPSGGFNFEY FNSWYPDIDD TAAAILAMVK QDPNLLDLGP
     ILSAVQWILG LQNDDGGWAA FDRENNYLFL NKIPFSDMDS FCDPSTADVT GRVIECFGLN
     GKNPIPRFFI DDMSSATERA IDFLSTEQEA DGSWYGRWGS NYIYGTSAVL CGLVYHLEGW
     DDTYPVMEKR HKVDTHAALD WLKRHQNPDG GWGERLESYY EPRLAGNGPS TASQTAWALM
     GLLAYLAPTD ESITRGIQYL SRTQIKEGEL AGSWKEDHYT GTGFPNHFYL CYTLYSQYFP
     MMALGRYTSL SGYRPLENLE STVEDHKGNS SDC
//

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