(data stored in SCRATCH zone)

SWISSPROT: A2Q7Q2_ASPNC

ID   A2Q7Q2_ASPNC            Unreviewed;       469 AA.
AC   A2Q7Q2;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 66.
DE   RecName: Full=Proline dehydrogenase {ECO:0000256|RuleBase:RU364054};
DE            EC=1.5.5.2 {ECO:0000256|RuleBase:RU364054};
GN   ORFNames=An01g01530 {ECO:0000313|EMBL:CAK43525.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK43525.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC       {ECO:0000256|RuleBase:RU364054}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC         quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC         ChEBI:CHEBI:132124; EC=1.5.5.2;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
CC       {ECO:0000256|RuleBase:RU364054}.
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DR   EMBL; AM269954; CAK43525.1; -; Genomic_DNA.
DR   RefSeq; XP_001388593.1; XM_001388556.1.
DR   PaxDb; A2Q7Q2; -.
DR   EnsemblFungi; CAK43525; CAK43525; An01g01530.
DR   GeneID; 4978371; -.
DR   KEGG; ang:ANI_1_2264014; -.
DR   HOGENOM; HOG000178664; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR002872; Proline_DH_dom.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914; PTHR13914; 1.
DR   Pfam; PF01619; Pro_dh; 1.
DR   SUPFAM; SSF51730; SSF51730; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q7Q2.
DR   SWISS-2DPAGE; A2Q7Q2.
KW   FAD {ECO:0000256|RuleBase:RU364054};
KW   Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364054,
KW   ECO:0000313|EMBL:CAK43525.1};
KW   Proline metabolism {ECO:0000256|RuleBase:RU364054}.
FT   DOMAIN          130..449
FT                   /note="Pro_dh"
FT                   /evidence="ECO:0000259|Pfam:PF01619"
FT   REGION          39..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  52267 MW;  82DAC5A06981C270 CRC64;
     MRSKVLLWPK RPTPLLYYQL LHHPPVYYHA YYNTSSTSTT TTHHTVPPPA PKTPSPAPLS
     ALPTRTFLRS LLFTSVMASP LLKPCLSLLK YMVDSNSLLF SPAKNPVVNY LLRRTIYDHF
     CAGINEREVR NTVQEMKSLG FKGVILGYAR ESIAKVEDVD RIQSAEEKQE ALDRAVEEWR
     VGTLRTLGMC GRGNYLAVKF TGAGPAAVEA LSRGDRVPPP RIQEAMMEIC DAVAAQGSRV
     WIDAEQQIFQ GAIDAWAVDL MRKYNRVNRA DAPVVLNTYQ AYLKSSTARL NEHLQLAQRE
     GWAMGVKLVR GAYIAHDHRD RIHDTKADTD RNYDHIVESL ITRQYPLGGE PGQPFPKVRL
     FVASHNGVSV RKACALYRQR AQSGLPLIPV EVGQLQGMAD EVSLGMVEGS TDGAAPGVFK
     CLAWGSTEEC LHFLLRRAVE NQSAMERTRD TARALRGEAW RRLGGGSVM
//

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