(data stored in SCRATCH zone)

SWISSPROT: A2Q7T6_ASPNC

ID   A2Q7T6_ASPNC            Unreviewed;       401 AA.
AC   A2Q7T6;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 69.
DE   SubName: Full=Aspergillus niger contig An01c0070, genomic contig {ECO:0000313|EMBL:CAK43559.1};
GN   ORFNames=An01g01880 {ECO:0000313|EMBL:CAK43559.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK43559.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000138-2,
CC         ECO:0000256|PROSITE-ProRule:PRU00683};
CC   -!- SIMILARITY: Belongs to the FMN-dependent alpha-hydroxy acid
CC       dehydrogenase family. {ECO:0000256|PROSITE-ProRule:PRU00683}.
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DR   EMBL; AM269954; CAK43559.1; -; Genomic_DNA.
DR   RefSeq; XP_001388627.1; XM_001388590.1.
DR   PaxDb; A2Q7T6; -.
DR   EnsemblFungi; CAK43559; CAK43559; An01g01880.
DR   GeneID; 4977180; -.
DR   KEGG; ang:ANI_1_238014; -.
DR   HOGENOM; HOG000217463; -.
DR   KO; K00467; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd03332; LMO_FMN; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012133; Alpha-hydoxy_acid_DH_FMN.
DR   InterPro; IPR000262; FMN-dep_DH.
DR   InterPro; IPR037396; FMN_HAD.
DR   InterPro; IPR008259; FMN_hydac_DH_AS.
DR   InterPro; IPR037350; LMO_FMN.
DR   Pfam; PF01070; FMN_dh; 1.
DR   PIRSF; PIRSF000138; Al-hdrx_acd_dh; 1.
DR   PROSITE; PS00557; FMN_HYDROXY_ACID_DH_1; 1.
DR   PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q7T6.
DR   SWISS-2DPAGE; A2Q7T6.
KW   Flavoprotein {ECO:0000256|PROSITE-ProRule:PRU00683};
KW   FMN {ECO:0000256|PIRSR:PIRSR000138-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00683}.
FT   DOMAIN          21..401
FT                   /note="FMN hydroxy acid dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51349"
FT   NP_BIND         327..351
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00683"
FT   NP_BIND         327..331
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2"
FT   ACT_SITE        296
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         47
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         130
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         153
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         155
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         183
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         192
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         272
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         294
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2"
FT   BINDING         299
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00683"
FT   BINDING         351
FT                   /note="FMN"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000138-2"
SQ   SEQUENCE   401 AA;  43652 MW;  298B4202920E0C6B CRC64;
     MPPPPPYTYQ SEVYTHGLRD QKPAITFIAS EWENLARARL SANSFSYVHG SAGTGETDRK
     NRSAFQSWSV IPSRLVPSAE FPDLSTTLFG KKYASPIAIA PVGVQTIFHP EGERAVARAA
     AGLDVPYTLS TATATSTEDV AEANGADGKR WFQLYWPGNE HNDITVSLLE RAKKSGYDVL
     VVTLDTYILG WRPTDMDNGY NPFLRADSIG VEMGFSDPVF RRYIRDKFGK EVEEDKGTAA
     GEWTKIVFPG VSHSWEDLAF LRSHWEGPIV LKGVQSVGDA RRAVECGMQG IVVSNHGGRQ
     MDGGVGSLTV LPGIVDAVGE KIEVLFDSGV RCGADVVKAL ALGAKMVLVG RPYVYGLAIA
     GEEGVRHVLR SLLGEVQLSL HLGGIRSVKK EDLNRDCLVR E
//

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