(data stored in SCRATCH zone)

SWISSPROT: A2Q880_ASPNC

ID   A2Q880_ASPNC            Unreviewed;      1116 AA.
AC   A2Q880;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   SubName: Full=Aspergillus niger contig An01c0100, genomic contig {ECO:0000313|EMBL:CAK36877.1};
GN   ORFNames=An01g03370 {ECO:0000313|EMBL:CAK36877.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK36877.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
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DR   EMBL; AM269957; CAK36877.1; -; Genomic_DNA.
DR   PaxDb; A2Q880; -.
DR   EnsemblFungi; CAK36877; CAK36877; An01g03370.
DR   HOGENOM; HOG000211257; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
DR   PRODOM; A2Q880.
DR   SWISS-2DPAGE; A2Q880.
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168,
KW   ECO:0000256|SAAS:SAAS01081641}.
FT   DOMAIN          407..532
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          660..898
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..278
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..323
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..355
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        395..412
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1116 AA;  124941 MW;  AC23CCDB74239C95 CRC64;
     MASQPLRRER ASSDKADVAP FPQRPGLPSR TISAPVGGLY RLDSARTAME SGNKVDRTLL
     EEDENPPSAG GDRVPSLSRE ETTPKPSFPH VSIAVVGPDH VGKSTFIETA LDMKHPLSSR
     STTKKMSLDG TVYLVRLMEI DTLEISIGSN GEVNWPLLGN DSPPTVDGVL VLLDMTQPAS
     FPEFTELLDS LTASDIPFTL VASKCDIQPP DSPVEPILGG YEIHRTSPDS PRSQKMCIAL
     VLRSVINRKY GFIDFPPNSS ATPDWHHSRT NSETPTAVLS GAAGGPITGP LDPAVDGYGV
     DRQPTEPATS ANLASNGQAF RYARSNSHPV RPHTPPSGSR LASRKQSVSG ESSPSKDLNR
     QHRLHTAWRN SGGSDAFSNF LEMGEDFDGP RSAPSSPGSK DQTPSESSSN DAGLTFDELV
     DRLVAQPMSK QDSKFASIFL CLYRKFAAPC TLLNALINRF ERNENDMTDQ LDRIAVQLRL
     LGVMAQWVSE YPGDLAYPKT RKRITDFVTT LEKSHFYMFA AKEIGSYLEG NAEDDNIGWP
     YRDGDMEEPD TADPPFQFSG RSSPSIFLGA PPLGDEGEEE EEDPIYNMSA LDLSEGAAEP
     ASRLSGSMSN SFTSEKPGTI ASQSFTFLST EAAQREAHNL DLTPRIPLTK VQWRQLMEIP
     DEDFARELTR IDWIMFNSFR PRDLVRHVSI SGVEKDKILS LKHVNRMIKQ FNHVAFFVAS
     VILLRDKPKH RAKALEKFMN IALKLRRLNN YNSLGAVIAG INGTPVHRLS QTRELVPVQT
     QKDFMRLVIL MGTQKSHFAY RLAWDNSFAE RIPFLPLHRR DLVSAEEGNK TFVGDNKNRI
     NWRKFEVMGE VVLGIQRSQK TPYPHMPKYE EVERLVLEIK LSGDDEDLYS RSMQVEPSAG
     GDTGRKKFGW LRSTSTKLTS TMNDDRHLID DDVHNVVSTT TRPYLVTNLR EKCKNHVIYN
     HRKPNLSVAH PPSNQTYHLH KSHIYNPHKL LKQNPKEKKK NIKMSTAIKT SYRALLRELP
     RRTLSTPTPL QHRLRDMYTT NQQQASVADA DAQEALRQHR IDQANQFAIY AKAQRVYAEL
     VERYNPGTTL DEEERIRLTA RRVGWDLPVE AGKKDE
//

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