(data stored in SCRATCH zone)

SWISSPROT: A2Q8A6_ASPNC

ID   A2Q8A6_ASPNC            Unreviewed;       585 AA.
AC   A2Q8A6;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 91.
DE   RecName: Full=Lysine--tRNA ligase {ECO:0000256|RuleBase:RU003748};
DE            EC=6.1.1.6 {ECO:0000256|RuleBase:RU003748};
DE   AltName: Full=Lysyl-tRNA synthetase {ECO:0000256|RuleBase:RU003748};
GN   ORFNames=An01g03650 {ECO:0000313|EMBL:CAK36903.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK36903.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-
CC         tRNA(Lys); Xref=Rhea:RHEA:20792, Rhea:RHEA-COMP:9696, Rhea:RHEA-
CC         COMP:9697, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6;
CC         Evidence={ECO:0000256|RuleBase:RU003748};
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DR   EMBL; AM269959; CAK36903.1; -; Genomic_DNA.
DR   PaxDb; A2Q8A6; -.
DR   EnsemblFungi; CAK36903; CAK36903; An01g03650.
DR   HOGENOM; HOG000236577; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004824; F:lysine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006430; P:lysyl-tRNA aminoacylation; IEA:InterPro.
DR   InterPro; IPR004364; Aa-tRNA-synt_II.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR002313; Lys-tRNA-ligase_II.
DR   InterPro; IPR018149; Lys-tRNA-synth_II_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   Pfam; PF00152; tRNA-synt_2; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   PRINTS; PR00982; TRNASYNTHLYS.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00499; lysS_bact; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   4: Predicted;
DR   PRODOM; A2Q8A6.
DR   SWISS-2DPAGE; A2Q8A6.
KW   Ligase {ECO:0000313|EMBL:CAK36903.1}.
FT   DOMAIN          231..560
FT                   /note="AA_TRNA_LIGASE_II"
FT                   /evidence="ECO:0000259|PROSITE:PS50862"
SQ   SEQUENCE   585 AA;  66122 MW;  E69890F866ABE768 CRC64;
     MQPIRPFRAS SLRVGGLLSR AGLPISRTSQ AFQTSGRLAR VIQHTLAPLV QTRHNSVDAY
     PEKAFKRRVQ LIEEAVAESY PRLASNKNTV SCAEFRGRYS HLADNEIVED DTVVINGRVR
     TLRLVGGNLI FFDLVHDGHK IQVMCNRRRL KDIPPATFKQ FYRMLRRGDA FSVTGNPHRT
     ERGELTVLAT ELPQLLSPCL HDIPVDAQGQ ENSPYPRHVQ FLADPETVNV IRARSAVVQY
     LRQFFVDRAF MEVNTPIIEA VAGGAIARPF HTTATEFPDR QLSLRIAPEL WLKRLVVGGF
     DRVFEIGPSF RNEGLDKTHN PEFTTCEFYH AYANLEDLMT TTEQLLSGLA EHLTAFHQSS
     PFKRPNQEDT PLPFSHLNFS APFRRLDFIT SIEQSIGQKL PDLASPDALE QVKAIFRDRN
     HALPDKVTLP RLLDELCSIY VEPQCIDPTF IVNPPECLSP LSKSFIHPTT NQRVAARGEL
     FIEGREVVNT YEEENSPFEQ RRKFEDQVRY SKQADEAEEI DESYLKALEW GLPPTGGWGC
     GIDRLCMLFT GMTRIGDILP FGNLRKVTTR ADAAAESQAT EGKEN
//

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