(data stored in SCRATCH zone)

SWISSPROT: A2Q8G4_ASPNC

ID   A2Q8G4_ASPNC            Unreviewed;       363 AA.
AC   A2Q8G4;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 79.
DE   RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000256|RuleBase:RU000554};
DE            EC=4.1.1.37 {ECO:0000256|RuleBase:RU000554};
GN   ORFNames=An01g04250 {ECO:0000313|EMBL:CAK36961.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK36961.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC         III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC         Evidence={ECO:0000256|RuleBase:RU000554};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC       {ECO:0000256|RuleBase:RU000554}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC       {ECO:0000256|RuleBase:RU004169}.
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DR   EMBL; AM269962; CAK36961.1; -; Genomic_DNA.
DR   RefSeq; XP_001388853.1; XM_001388816.1.
DR   PaxDb; A2Q8G4; -.
DR   EnsemblFungi; CAK36961; CAK36961; An01g04250.
DR   GeneID; 4978301; -.
DR   KEGG; ang:ANI_1_542014; -.
DR   HOGENOM; HOG000253896; -.
DR   KO; K01599; -.
DR   UniPathway; UPA00251; UER00321.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00717; URO-D; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   HAMAP; MF_00218; URO_D; 1.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   Pfam; PF01208; URO-D; 1.
DR   SUPFAM; SSF51726; SSF51726; 1.
DR   TIGRFAMs; TIGR01464; hemE; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q8G4.
DR   SWISS-2DPAGE; A2Q8G4.
KW   Decarboxylase {ECO:0000256|RuleBase:RU000554};
KW   Lyase {ECO:0000256|RuleBase:RU000554, ECO:0000313|EMBL:CAK36961.1};
KW   Porphyrin biosynthesis {ECO:0000256|RuleBase:RU000554}.
FT   DOMAIN          26..35
FT                   /note="Uroporphyrinogen_deCOase"
FT                   /evidence="ECO:0000259|PROSITE:PS00906"
FT   DOMAIN          151..167
FT                   /note="Uroporphyrinogen_deCOase"
FT                   /evidence="ECO:0000259|PROSITE:PS00907"
SQ   SEQUENCE   363 AA;  40774 MW;  1625AEA2932437ED CRC64;
     MQHQFEPLKN DLLLRAARGE KVQRPPIWVM RQAGRYLPEY HEAKAGRDFF ECCRDPEVAS
     TLTIQPIDRY AGLIDAAIIF SDILVIPQAM GMQVEMVDKK GPHFPEPLQS PDDGQYEKVM
     QKDVDVKSEL DYVYKAITLT RHKLQGRVPL IGFCGAPWTL LCYMVEGGGT KLFVQSKKWI
     YKYPKESQAL LQKIAEICVE YLALQVAAGA QLVQVFDSWA GELSPAAFKS FSLPYLRHIS
     ANLPKKLKEM GLEPVPMTVF AKGAWFGLED LCESGYNVVG LDWLHDPAEA RRIANGRVTI
     QGNADPGVLY GGREAITEAV ETMVRGFEKG KQGWIANLGH GVTPFVNPDD LKFFFEEIHR
     LTV
//

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