(data stored in SCRATCH zone)

SWISSPROT: A2Q8I3_ASPNC

ID   A2Q8I3_ASPNC            Unreviewed;       997 AA.
AC   A2Q8I3;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   11-DEC-2019, entry version 75.
DE   RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE            EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
GN   ORFNames=An01g04450 {ECO:0000313|EMBL:CAK36980.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK36980.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|RuleBase:RU363067};
CC       Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC       preferentially bind zinc ions, while site 2 has a preference for
CC       magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
CC       {ECO:0000256|RuleBase:RU363067, ECO:0000256|SAAS:SAAS01040771}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM269963; CAK36980.1; -; Genomic_DNA.
DR   PaxDb; A2Q8I3; -.
DR   EnsemblFungi; CAK36980; CAK36980; An01g04450.
DR   HOGENOM; HOG000210878; -.
DR   Proteomes; UP000006706; Chromosome 2R.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.1300.10; -; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR023088; PDEase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   InterPro; IPR023174; PDEase_CS.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS00126; PDEASE_I_1; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A2Q8I3.
DR   SWISS-2DPAGE; A2Q8I3.
KW   Hydrolase {ECO:0000256|RuleBase:RU363067, ECO:0000256|SAAS:SAAS01040760,
KW   ECO:0000313|EMBL:CAK36980.1};
KW   Metal-binding {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS01040765}.
FT   DOMAIN          270..626
FT                   /note="PDEase"
FT                   /evidence="ECO:0000259|PROSITE:PS51845"
FT   REGION          667..766
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          786..997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..714
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..759
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..870
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..891
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        892..912
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        928..947
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        949..964
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        965..988
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   997 AA;  109905 MW;  2A02C44166E16A1F CRC64;
     MDGIECSAIY IDHRVRSERW VYQGTPEAPA GAESDSGIIE EPESLSSDVQ VLLGVCKRIY
     LCQVGTAIAN KLAEISDGAQ SRCTPIFVFF DIDIHGEEAA LQRRRASRGS WPDVSPPSPA
     SLRRGFTFTS QWEGAYDLKL LSGLSADIQV QDGPNVIVPV AVLRPPFADP TSASPADQPR
     IPSFPDPQHI SKCLDAGAVD VLVTPLDSCR AQALVVQAYR TRKTALREQS RFLSRKKLRK
     HSWVGVNDEQ PYAYLREAMV SKLMRGICNP EEVIEEFQDR ELDVRPDRAD FVREHIAQWG
     FTAHEFSDDE LVLAAFEMLQ HALQYPELEQ WQLTPGELRT FLLACRASYN SFVLYHNFRH
     AIDVLQSVFC FLLHIGALPP YGPNSPTIDD KCPMASLLTP FDTLTLLISA IGHDVGHPGV
     NNFFLVKLNA PLAQLYNDNS VLEAFHCAAF SQILRRYWPT AFKDRQLRKL LISSILATDM
     GVHQKFMERL GSLQEKFHEN NRTVDGWKPQ DLELYKTLLC GLLIKCADIS NVARPWDVAE
     KWTQILQEEF ANQGEMEKEV GMETALFGGP PELGNIYKLA TGQIGFMSIF ALPLFEGVSD
     ILPDLKFTVE HIRSNQSKWH FLADMEKNRQ TLQIDLRPDD LVSPRTQSPI PSLRGLHAPL
     AINSPKMPIK PALPTSEPVS QRSTADDYFG TASTPLASDD SPSDYNENTI SPVVSPDTPG
     PPMDITGCSM PSPDEAASRR SSGVIPEGQT NSPSARLSDN MDGCSDAIRA SSDPTVLAAV
     LFANGSAAGN GDTSGRSSAR NSSVEGRPSS SRHGPPSGRR QHANTASSGR TSGPSNSQRN
     SCTRTHSVST YSNNMTPISP STNATSFLSV DSDEKGFPRE SISRSDGEWD RANTRPATSN
     HPSVNAAYPS TRRASDPHNY DAAKVTSPVG YGTSSSAQST TTTGSMKHEG RGPRWDEHGS
     KEHAPPRKLP KRRSRLRLAF WKRRTHHSHQ HEVSGET
//

If you have problems or comments...

PBIL Back to PBIL home page