(data stored in SCRATCH zone)

SWISSPROT: A4ATA3_MARSH

ID   A4ATA3_MARSH            Unreviewed;       341 AA.
AC   A4ATA3;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN   OrderedLocusNames=FB2170_16351 {ECO:0000313|EMBL:EAR00673.1};
OS   Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Maribacter.
OX   NCBI_TaxID=313603 {ECO:0000313|EMBL:EAR00673.1, ECO:0000313|Proteomes:UP000001602};
RN   [1] {ECO:0000313|EMBL:EAR00673.1, ECO:0000313|Proteomes:UP000001602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX   PubMed=21037013; DOI=10.1128/JB.01207-10;
RA   Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA   Cho J.C.;
RT   "Complete genome sequence of strain HTCC2170, a novel member of the
RT   genus Maribacter in the family Flavobacteriaceae.";
RL   J. Bacteriol. 193:303-304(2011).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC       {ECO:0000256|RuleBase:RU362028}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a psi-uridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-
CC         COMP:12069, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|RuleBase:RU362028};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|RuleBase:RU362028, ECO:0000256|SAAS:SAAS01177972}.
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DR   EMBL; CP002157; EAR00673.1; -; Genomic_DNA.
DR   RefSeq; WP_013304476.1; NC_014472.1.
DR   STRING; 313603.FB2170_16351; -.
DR   EnsemblBacteria; EAR00673; EAR00673; FB2170_16351.
DR   KEGG; fbc:FB2170_16351; -.
DR   eggNOG; ENOG4105C34; Bacteria.
DR   eggNOG; COG0564; LUCA.
DR   HOGENOM; HOG000275919; -.
DR   KO; K06180; -.
DR   OMA; KRVDKRY; -.
DR   OrthoDB; 1714699at2; -.
DR   BioCyc; MSP313603:G1GNS-49-MONOMER; -.
DR   Proteomes; UP000001602; Chromosome.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluCD_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4ATA3.
DR   SWISS-2DPAGE; A4ATA3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001602};
KW   Isomerase {ECO:0000256|RuleBase:RU362028,
KW   ECO:0000256|SAAS:SAAS00999454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001602};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182,
KW   ECO:0000256|SAAS:SAAS00999393}.
FT   DOMAIN       29    102       S4 RNA-binding. {ECO:0000259|PROSITE:
FT                                PS50889}.
SQ   SEQUENCE   341 AA;  38817 MW;  1F607CC3154CF4E2 CRC64;
     MESAMGPELN DEELYEHHKF IASKGQEPLR VDKFLMNFIE NATRNKIQQA AKDGHIWVNE
     KIVKQNYKVK AGDEVKVLFE HPPYELLLTP ENIPLDIVYE DDVLLVVNKP AGMVVHPGHG
     NYTGTLINAL LYHSKDLPVN SNDRPGLVHR IDKDTSGLLV VAKTEAAMTH LAKQFFDKTS
     EREYVALVWG NVEDESGTIE GNIARNPKNR LQMQVFPEGE QGKEAVTHYG VLERLGYVTL
     VSCKLETGRT HQIRVHMKYI GHTLFNDERY GGDKVLKGTT FTKYKQFVDN AFKILPRQAL
     HAKTLGFVHP VSGEMMRFDS EIPEDMSLCI DKWKDYAKHS M
//

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