(data stored in SCRATCH zone)

SWISSPROT: A4ATR3_MARSH

ID   A4ATR3_MARSH            Unreviewed;       193 AA.
AC   A4ATR3;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   SubName: Full=Uroporphyrin-III C-methyltransferase {ECO:0000313|EMBL:EAR00833.1};
GN   OrderedLocusNames=FB2170_17151 {ECO:0000313|EMBL:EAR00833.1};
OS   Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Maribacter.
OX   NCBI_TaxID=313603 {ECO:0000313|EMBL:EAR00833.1, ECO:0000313|Proteomes:UP000001602};
RN   [1] {ECO:0000313|EMBL:EAR00833.1, ECO:0000313|Proteomes:UP000001602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX   PubMed=21037013; DOI=10.1128/JB.01207-10;
RA   Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA   Cho J.C.;
RT   "Complete genome sequence of strain HTCC2170, a novel member of the
RT   genus Maribacter in the family Flavobacteriaceae.";
RL   J. Bacteriol. 193:303-304(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC         Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827;
CC         EC=1.3.1.76; Evidence={ECO:0000256|SAAS:SAAS01123666};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC       {ECO:0000256|SAAS:SAAS01024982}.
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DR   EMBL; CP002157; EAR00833.1; -; Genomic_DNA.
DR   RefSeq; WP_013304636.1; NC_014472.1.
DR   STRING; 313603.FB2170_17151; -.
DR   EnsemblBacteria; EAR00833; EAR00833; FB2170_17151.
DR   KEGG; fbc:FB2170_17151; -.
DR   eggNOG; ENOG4108Z73; Bacteria.
DR   eggNOG; COG1648; LUCA.
DR   HOGENOM; HOG000285944; -.
DR   KO; K02304; -.
DR   OMA; VNMMVKQ; -.
DR   OrthoDB; 1185397at2; -.
DR   BioCyc; MSP313603:G1GNS-206-MONOMER; -.
DR   UniPathway; UPA00262; UER00222.
DR   Proteomes; UP000001602; Chromosome.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR028161; Met8.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028281; Sirohaem_synthase_central.
DR   InterPro; IPR006367; Sirohaem_synthase_N.
DR   PANTHER; PTHR35330; PTHR35330; 1.
DR   Pfam; PF14824; Sirohm_synth_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01470; cysG_Nterm; 1.
PE   4: Predicted;
DR   PRODOM; A4ATR3.
DR   SWISS-2DPAGE; A4ATR3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001602};
KW   Methyltransferase {ECO:0000313|EMBL:EAR00833.1};
KW   NAD {ECO:0000256|SAAS:SAAS01024985};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS01024988};
KW   Porphyrin biosynthesis {ECO:0000256|SAAS:SAAS01024977};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001602};
KW   Transferase {ECO:0000313|EMBL:EAR00833.1}.
FT   DOMAIN      125    149       Sirohm_synth_M. {ECO:0000259|Pfam:
FT                                PF14824}.
SQ   SEQUENCE   193 AA;  22111 MW;  7740A0311F77EE5D CRC64;
     MERNNLYPIF LKTSKLTILI IGGGEVAEEK LRFLTKSSPD ANITIVSPMF RDETLILAKK
     FEAVLIKETY HKRHLDGMHL VVATTDNPNV NLKVYKDCRQ QDKLVNVADN PPYCDFYMGG
     IVTKGNVKIA ISTNGQSPTT AKRLRQFFEE VIPEDIDEMV RNLNSYRKRL KDDFGQKVDK
     MNRLTRSLVN SDE
//

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