(data stored in SCRATCH zone)

SWISSPROT: A4F5P6_SACEN

ID   A4F5P6_SACEN            Unreviewed;       304 AA.
AC   A4F5P6;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 63.
DE   RecName: Full=S-adenosyl-L-methionine-dependent methyltransferase {ECO:0000256|RuleBase:RU362030};
DE            EC=2.1.1.- {ECO:0000256|RuleBase:RU362030};
GN   OrderedLocusNames=SACE_0017 {ECO:0000313|EMBL:CAL99370.1};
GN   ORFNames=A8924_0400 {ECO:0000313|EMBL:PFG93170.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99370.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99370.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99370.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93170.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93170.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent
CC       methyltransferase activity. {ECO:0000256|RuleBase:RU362030,
CC       ECO:0000256|SAAS:SAAS00275398}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family.
CC       {ECO:0000256|RuleBase:RU362030, ECO:0000256|SAAS:SAAS00558698}.
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DR   EMBL; AM420293; CAL99370.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93170.1; -; Genomic_DNA.
DR   RefSeq; WP_009945676.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0017; -.
DR   EnsemblBacteria; CAL99370; CAL99370; SACE_0017.
DR   KEGG; sen:SACE_0017; -.
DR   eggNOG; ENOG4105JQZ; Bacteria.
DR   eggNOG; COG3315; LUCA.
DR   HOGENOM; HOG000253066; -.
DR   OMA; AFETIHY; -.
DR   OrthoDB; 847145at2; -.
DR   BioCyc; SERY405948:SACE_RS00080-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0018423; F:protein C-terminal leucine carboxyl O-methyltransferase activity; IEA:InterPro.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F5P6.
DR   SWISS-2DPAGE; A4F5P6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Methyltransferase {ECO:0000256|RuleBase:RU362030,
KW   ECO:0000256|SAAS:SAAS00444613, ECO:0000313|EMBL:PFG93170.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU362030,
KW   ECO:0000256|SAAS:SAAS00275397};
KW   Transferase {ECO:0000256|SAAS:SAAS00444605,
KW   ECO:0000313|EMBL:PFG93170.1}.
SQ   SEQUENCE   304 AA;  33269 MW;  0F4E5F8F4ED55B55 CRC64;
     MTLAGKVRAA KGATSPTAEL CAVIRAAETQ QPERSRLLDD PFAQYFLQNW RFRTTHPFPP
     VFRLCLRMAD RRYTGLLAEV VLRHRFCDEV VEAEVAAGCT QVVLLGAGYD TTALRHDFGP
     GVVVYEVDKP DTQAEKTAIM RRNSLRPKGR VQYVTCDFAA GDDLGERLTS QGFDPALPSV
     VLWMGVTYYL PGDSVLDTLG KLGAITAPGS KVVLDYMDAS VVSGSGDDSA RRARQLVASG
     GEPFVFGVES DDIRAFCDAG GFGVAEHHRI PDLLRRYGDD DRFWLTVVDY MGVVVLEKEN
     APAA
//

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