(data stored in SCRATCH zone)

SWISSPROT: A4F5Q2_SACEN

ID   A4F5Q2_SACEN            Unreviewed;      2322 AA.
AC   A4F5Q2;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:CAL99376.1};
DE            EC=4.2.1.60 {ECO:0000313|EMBL:CAL99376.1};
DE   SubName: Full=PfaB family protein {ECO:0000313|EMBL:PFG93176.1};
GN   OrderedLocusNames=SACE_0023 {ECO:0000313|EMBL:CAL99376.1};
GN   ORFNames=A8924_0406 {ECO:0000313|EMBL:PFG93176.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99376.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99376.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99376.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93176.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93176.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
CC       {ECO:0000256|RuleBase:RU003694}.
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DR   EMBL; AM420293; CAL99376.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93176.1; -; Genomic_DNA.
DR   RefSeq; WP_009945667.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0023; -.
DR   PRIDE; A4F5Q2; -.
DR   EnsemblBacteria; CAL99376; CAL99376; SACE_0023.
DR   KEGG; sen:SACE_0023; -.
DR   eggNOG; ENOG4108JVF; Bacteria.
DR   eggNOG; COG0764; LUCA.
DR   HOGENOM; HOG000294474; -.
DR   OMA; LTYRMEV; -.
DR   OrthoDB; 1123553at2; -.
DR   BioCyc; SERY405948:SACE_RS00110-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.366.10; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013114; FabA_FabZ.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF07977; FabA; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   SUPFAM; SSF53901; SSF53901; 3.
DR   SUPFAM; SSF54637; SSF54637; 4.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F5Q2.
DR   SWISS-2DPAGE; A4F5Q2.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Lyase {ECO:0000313|EMBL:CAL99376.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transferase {ECO:0000256|RuleBase:RU003694}.
FT   DOMAIN        7    451       PKS_KS. {ECO:0000259|SMART:SM00825}.
FT   DOMAIN     1011   1335       PKS_AT. {ECO:0000259|SMART:SM00827}.
FT   COILED     1471   1491       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2322 AA;  249419 MW;  BD4A60D6C60BCAAB CRC64;
     MSSGTPIAVV GMSCLLPGAS TPEEFWASLR EGADQRSHGG REVFGTDPSV PGGWGDDQHS
     ITTTRGGFVG EVETDLEGLG LPAEELDGLG RVVRWPLHTA RRALADAGLP ESGEGLARTG
     LVLGNYSFPT EESTRFVLPM LRAQVSDGLR RAGLPLPDDA SPRPDADPRS VWASGLPACV
     VHTALGLGGP HLALDAACSS TLYGIALARD YLLTGAADVM LAGAVCAPDP LLIQLSFSDL
     RALPSDDDVS QPFDARSSGI VTGQGAGAFV LKRLPDALAD GDRVHAVVES IGLGNDGAGR
     HVLSPDAAGQ LDAYRAAYAD VDPATVDYVE CHATGTPLGD STELRSLSEF FDGRGSAPLL
     GSVKGNVGHL LTAAGLTSML KVIMAMREGR IPATPGVGEA LSPSGGEAAA RRVVLEERAW
     PETAGRPRRA GVSAFGFGGT NAHLVLSSEP GPEPSRHAPS RRVPRMAVTG VGARLGPLET
     TAPLQRKVRR AESGLRERPA GRWYGADDIA EPPGELGESG YAEQLKVDLS TYRIPPFELN
     QANPQHLMMF EAADAALADA GFDQPEETSG AERRPARRVA VVVAMEMEPH THTHRARFDI
     GAHVRAECAR AGVELGGEVL KRLERSVRDA VHEPIGANEV LSYIGNIMSS RISASRNLVG
     PSFTISADRT AGARAVEIAG LLLLDESIEA VVVGGVDLAC GPANVNARAR LADERGEELP
     PLGDGAAAVV LTRAGQVGPE GQEYATVDSV SLRPDPGSAA REALRAAGSD ASEVDYLELG
     SATSDGLATE VAELAGAYRA DDLSCAVGGL APLVGDTQAG CAVASLVKVA LCLDGAELPA
     TPAEPPLAGP ELAESAFYRV DEPRPWLRRH RDGRRIAALS AVGSGTAAHL VLSSGQVATG
     DAVRTAHVAG PLVLALSADD AEGIAEQAAR CAAELDSGGD ALALCWEHAH GAQSARLTAV
     LVSDSGDGLR EELRSAERDL PAAVADGEWS TPAGSFCTGR PLGPQGRVAL VYPGAFTTYP
     GAGREMFRLF PELLADFEAE CEHPAERFKH RELYPRAREP LDRRTLLRHE AELLDDIPVM
     LATGTNFAVL ATRMLRDVLG VRPDGGFGYS LGESSMLFAT GVWSAQARDD TALAASPLFR
     DELRGPKRQV RRSWDLAPET ADSAVWSTHV LLADPETVRG HMRELDRVFL THVNTPEEVV
     VAGDPGQCRA LVERVGCQAA KAPANHVMHV PLVDPHLDAL AALNDYPLGD PDPGLELLSA
     YDYEPVDFAD RGRIAERIAR TLRGPIDFAR LARTAHERGF RYFVEVGPGS TCTRWIDDTL
     DGREHVAVSL DRRGAPAGAS LARAVARLVS HGMRVDLTRL LGMPDSTAQA PTTHVVPCGG
     ESVVERVREA AEPVLHAAVQ AEDRDAGPAD DEAITIEREP FVHLTTVTHA VPTQRGAPPA
     RQHGQRSSPP EQRRAPGPVQ AIAATVGRAH RSALRTQAAL QECALRELER TEPDASGNGS
     AHGTEPPAAD PGGPADPPSG GPTGGRPGVV WGESDLLEFA QGRISEVFGP SYAEIDSYPV
     RVRLPAPPYL FVSRVTDLDA RPGQYEPSSL TTEYDVPDDP WYAVDGLVPC AVTIEAGQCD
     MLLISYLGID FRNRGERVYR LLDSSLVFHG DLPRRGQTLR YEIGIDRFVS TGDRLLFFFD
     YRCYADGELI LELLEASAGF FSREELDESL GIVETDADRR RREAMTPSDF KPLARTGRTS
     LTAADLRLLA QGRPGEVFGP SWDQSADGFN PSLRLPGDAL RMIDEMPRIE RQGGPRELGD
     LAAVKHLDPD GWYFECHFPG DPVLAGSLVA EGGVQILQVY AMYLGLHLVL PDAEFQSVPG
     LRTEVKVRGQ ITPQTPRIDY HVEITEITML PRPTVIADIT VYDGDKPIVA MRDFGVQVRE
     KPGTPYRPGA GGVPEVRPRR NESGEAAFIN ELHLAHAAKG HLGTAMGPEF DVYDDRRAPH
     IPNGDFRFVD RIMRLDGTRG RLEPGVSMAT EYDCPPEAWF HREAAVEDIP NCVYMETSLQ
     AAILLGYYLG ATLEHPHQEL SIRNLDGNAE LVKRVDLRGR TIRHETTMLS SGTATGAILQ
     RFRYELSADG EVFYRGESLF GYFTEQALAN QVGLDSGSHV APWLDRQTDI DPARVRTVPV
     RSDERWFTPR DGLRLSGGHL RLVDEVDLVE DGGEHGRGYL RGRREIDPHE WYFDCHFHRD
     PVMPGSLGVE AVIQALHLYV LETGLAGHLG EATFATPVDE RMEWKYRGQI LRTDGEMTFD
     AHITDVRVDD DRVVVVADAN VWKPGLRIYE LTGVAVQARR VS
//

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