(data stored in SCRATCH zone)

SWISSPROT: A4F5W3_SACEN

ID   A4F5W3_SACEN            Unreviewed;       460 AA.
AC   A4F5W3;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 63.
DE   SubName: Full=DHA2 family methylenomycin A resistance protein-like MFS transporter {ECO:0000313|EMBL:PFG93236.1};
DE   SubName: Full=Drug resistance transporter, EmrB/QacA family {ECO:0000313|EMBL:CAL99437.1};
GN   OrderedLocusNames=SACE_0084 {ECO:0000313|EMBL:CAL99437.1};
GN   ORFNames=A8924_0469 {ECO:0000313|EMBL:PFG93236.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99437.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99437.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99437.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93236.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93236.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAL99437.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93236.1; -; Genomic_DNA.
DR   RefSeq; WP_009949859.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0084; -.
DR   EnsemblBacteria; CAL99437; CAL99437; SACE_0084.
DR   KEGG; sen:SACE_0084; -.
DR   eggNOG; ENOG4108HMV; Bacteria.
DR   eggNOG; ENOG410ZVNK; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   KO; K08166; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; SERY405948:SACE_RS00395-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
DR   PRODOM; A4F5W3.
DR   SWISS-2DPAGE; A4F5W3.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        305..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        432..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..458
FT                   /note="MFS"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   460 AA;  46177 MW;  EB81116EB144D1C3 CRC64;
     MTPTVEITAP PRRRLLLWVM CVGMFLVQLD VTVVNVALPR IGAELAPDLS AQQWVVDAYA
     VVLAGLLLAG GAVGDRYGHR RVVLAGLGVF AAASLACGLA PDIAVLVGGR AAQGLGAAML
     LPSTLAVITR AFPDRAEQAR AVGVWAGTSA LALPAGPLIG GALVSTLGWR SAFLVNLPVI
     AVALPLAYGV VAESADRGVR SLDLPGAALA TAGLAAPVYA VIEAGAAGMT TSAWGALAIS
     ALAVTGFLLR ESRAPQPLLP LRLLRSRRFS GANLVAAAMN LVGIGTVFVT TLYLQGVQHR
     NAATAGAMLL PLFVPMAALA PVTGRLTGRF GPRPPMTAGL VIGAAGAASL VGITPDSGYA
     RLLPALLGLG TGMGLLTAAV VAAAVRAVPA DRAGLAGGVN NTARQTAGAL AVAVFGGITG
     GPADAVRFTG GLHLLGLLSC ALWISALALT WFAIPAEKAW
//

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