(data stored in SCRATCH zone)

SWISSPROT: A4F5Z3_SACEN

ID   A4F5Z3_SACEN            Unreviewed;       275 AA.
AC   A4F5Z3;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 87.
DE   SubName: Full=Formamidopyrimidine-DNA glycosylase {ECO:0000313|EMBL:CAL99467.1};
DE            EC=3.2.2.23 {ECO:0000313|EMBL:CAL99467.1};
GN   Name=fpg {ECO:0000313|EMBL:CAL99467.1};
GN   Synonyms=mutM {ECO:0000313|EMBL:CAL99467.1};
GN   OrderedLocusNames=SACE_0114 {ECO:0000313|EMBL:CAL99467.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99467.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99467.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in
CC         DNA is broken by a beta-elimination reaction, leaving a 3'-
CC         terminal unsaturated sugar and a product with a terminal 5'-
CC         phosphate.; EC=4.2.99.18;
CC         Evidence={ECO:0000256|SAAS:SAAS01121890};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS00610166};
CC   -!- SIMILARITY: Belongs to the FPG family.
CC       {ECO:0000256|SAAS:SAAS00557294}.
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DR   EMBL; AM420293; CAL99467.1; -; Genomic_DNA.
DR   STRING; 405948.SACE_0114; -.
DR   EnsemblBacteria; CAL99467; CAL99467; SACE_0114.
DR   KEGG; sen:SACE_0114; -.
DR   eggNOG; ENOG4105EQC; Bacteria.
DR   eggNOG; COG0266; LUCA.
DR   HOGENOM; HOG000020886; -.
DR   KO; K10563; -.
DR   OMA; LQYCPTC; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0008534; F:oxidized purine nucleobase lesion DNA N-glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   Gene3D; 3.20.190.10; -; 1.
DR   InterPro; IPR015886; DNA_glyclase/AP_lyase_DNA-bd.
DR   InterPro; IPR015887; DNA_glyclase_Znf_dom_DNA_BS.
DR   InterPro; IPR012319; FPG_cat.
DR   InterPro; IPR035937; MutM-like_N-ter.
DR   InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR   InterPro; IPR000214; Znf_DNA_glyclase/AP_lyase.
DR   InterPro; IPR010663; Znf_FPG/IleRS.
DR   Pfam; PF01149; Fapy_DNA_glyco; 1.
DR   Pfam; PF06831; H2TH; 1.
DR   Pfam; PF06827; zf-FPG_IleRS; 1.
DR   SMART; SM00898; Fapy_DNA_glyco; 1.
DR   SMART; SM01232; H2TH; 1.
DR   SUPFAM; SSF46946; SSF46946; 1.
DR   SUPFAM; SSF81624; SSF81624; 1.
DR   PROSITE; PS01242; ZF_FPG_1; 1.
DR   PROSITE; PS51066; ZF_FPG_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F5Z3.
DR   SWISS-2DPAGE; A4F5Z3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728};
KW   DNA damage {ECO:0000256|SAAS:SAAS01087016};
KW   DNA repair {ECO:0000256|SAAS:SAAS01087019};
KW   DNA-binding {ECO:0000256|SAAS:SAAS01087047};
KW   Glycosidase {ECO:0000256|SAAS:SAAS01087011,
KW   ECO:0000313|EMBL:CAL99467.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01087030,
KW   ECO:0000313|EMBL:CAL99467.1}; Lyase {ECO:0000256|SAAS:SAAS01087025};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00551678};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS01087023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Zinc {ECO:0000256|SAAS:SAAS00551670};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00391,
KW   ECO:0000256|SAAS:SAAS00551733}.
FT   DOMAIN      226    260       FPG-type. {ECO:0000259|PROSITE:PS51066}.
SQ   SEQUENCE   275 AA;  29649 MW;  D61D9C22DBAA3DEB CRC64;
     MAQHLRDNAT GRSVARVDIA SLSVLKTVSP PWSELHGRTV TGATRYGKYL DLDCEGLHLV
     FHLARAGWMR WSDSLSPAPP KPGRGPIALR VHLGGGVGFD LTEAGTQKKL SAWVVEDPAE
     VPGIAKLGPD ALSLDVEGLT AVLSGRTERI KTVLTDQSMI AGIGNAYSDE ILHAAKLSPY
     ATAGRLDADA VERLHATMRE ILTDAVERSL KQDAARLKAE KRSGMRVHGR TGLPCPVCGD
     KVREVSFADR SLQYCATCQT GGRPLADRRL SRLLK
//

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