(data stored in SCRATCH zone)

SWISSPROT: A4F6A9_SACEN

ID   A4F6A9_SACEN            Unreviewed;       320 AA.
AC   A4F6A9;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:CAL99583.1};
DE            EC=1.3.1.12 {ECO:0000313|EMBL:CAL99583.1};
GN   Name=tyrA {ECO:0000313|EMBL:CAL99583.1};
GN   OrderedLocusNames=SACE_0231 {ECO:0000313|EMBL:CAL99583.1};
GN   ORFNames=A8924_0623 {ECO:0000313|EMBL:PFG93385.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99583.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99583.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99583.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93385.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93385.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAL99583.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93385.1; -; Genomic_DNA.
DR   RefSeq; WP_009944877.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0231; -.
DR   EnsemblBacteria; CAL99583; CAL99583; SACE_0231.
DR   KEGG; sen:SACE_0231; -.
DR   eggNOG; ENOG4105EVN; Bacteria.
DR   eggNOG; COG0287; LUCA.
DR   HOGENOM; HOG000043495; -.
DR   KO; K04517; -.
DR   OMA; MWRDICL; -.
DR   OrthoDB; 533829at2; -.
DR   BioCyc; SERY405948:SACE_RS01135-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003099; Prephen_DH.
DR   Pfam; PF02153; PDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
DR   PRODOM; A4F6A9.
DR   SWISS-2DPAGE; A4F6A9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Oxidoreductase {ECO:0000313|EMBL:CAL99583.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    320       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011934034.
FT   DOMAIN        2    286       Prephenate/arogenate dehydrogenase.
FT                                {ECO:0000259|PROSITE:PS51176}.
SQ   SEQUENCE   320 AA;  32500 MW;  F792960B93E259CB CRC64;
     MRAVCVIGLG LIGGSVLRAA SAAGRPAWGA TASRPDADAA RAEGFAVEDS AEDALRRAAA
     EDALVVVATP LTAVREVLRQ VAWHAPEAWL TDVVSVKDPV EAEVRSLLPG AKYAGGHPMA
     GLAESGWRAG SAELFSGASW AVTIEDGTTA PAWREAAALA VDCGARVVPC SAAEHDSAVA
     RVSHLPHVFA AVLAAVGADG GPLALSLAAG SFRDGTRVAG SAPDLVRAMT EGNRVALLDA
     VDDALGRLGA ARGSLASTGS LKSTVDAGHE ARRALEAAPE PRSLRVRLDE KGALDRLRDV
     GARGGRVVAL DEDAATVEVP
//

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