(data stored in SCRATCH zone)

SWISSPROT: A4F773_SACEN

ID   A4F773_SACEN            Unreviewed;       531 AA.
AC   A4F773;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   SubName: Full=Benzoylformate decarboxylase {ECO:0000313|EMBL:CAL99897.1};
DE            EC=4.1.1.7 {ECO:0000313|EMBL:CAL99897.1};
GN   Name=mdlC {ECO:0000313|EMBL:CAL99897.1};
GN   OrderedLocusNames=SACE_0551 {ECO:0000313|EMBL:CAL99897.1};
GN   ORFNames=A8924_0951 {ECO:0000313|EMBL:PFG93700.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99897.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99897.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99897.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93700.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93700.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; AM420293; CAL99897.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93700.1; -; Genomic_DNA.
DR   RefSeq; WP_009945224.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0551; -.
DR   EnsemblBacteria; CAL99897; CAL99897; SACE_0551.
DR   KEGG; sen:SACE_0551; -.
DR   eggNOG; ENOG4105FP9; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000244185; -.
DR   KO; K01576; -.
DR   OMA; DYEMIAR; -.
DR   OrthoDB; 391134at2; -.
DR   BioCyc; SERY405948:SACE_RS02710-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0050695; F:benzoylformate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
PE   3: Inferred from homology;
DR   PRODOM; A4F773.
DR   SWISS-2DPAGE; A4F773.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Lyase {ECO:0000313|EMBL:CAL99897.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        8    170       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      190    323       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      378    521       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   531 AA;  56750 MW;  B6623C2D24EC4827 CRC64;
     MPEETSTVRD ITRGLLRRLG LTTVFGNPGT TEVPFLTDWP DDFRYVLGLQ ESAVVAMADG
     YAQARREPVL VNLHSAGGVG HALGSVFTAY RNRTPMIVTA GQQTRSLMFG EPFLGATDAA
     SFPQPYVKWS YEPARAADVP AALMRAYQIA TQPPYGPVFV SIPADDWDQP GVEVADRPRT
     RGFAADPDSV AELAEALNSC ERPAFVVGPA VDGDGVVDEM VRLAEKARAE VWVSPMSPRC
     SFPEDHPAFA GFLHPERKAL SKELAAYDLV VVWGAPAFTY HVYRGESDVE LPEMFVVHDD
     PDVLARAVRG RGVLGTLAHS VRQVSALVGQ SDRAEPRGCE RPDKPAPSTP MTAAYVFDTI
     SSALPDDAAV VEETPSHRND LHDHFPIRST DGGFFTCASG ALGYGIGAAV GVAMADQTRR
     TVALLGDGSS MYGVQALWTA AREQTPVTFV IMDNSRYAAV AVLGEAAGGS KLPGVELGGI
     DFVGLATSLG VPAKSVNTPE ELDAALGEEF TTMNGPSLLH VKVDPGQRYL Y
//

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