(data stored in SCRATCH zone)

SWISSPROT: A4F7C5_SACEN

ID   A4F7C5_SACEN            Unreviewed;       560 AA.
AC   A4F7C5;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 64.
DE   SubName: Full=Acetolactate synthase large subunit {ECO:0000313|EMBL:CAL99949.1};
DE            EC=2.2.1.6 {ECO:0000313|EMBL:CAL99949.1};
DE   SubName: Full=Acetolactate synthase-1/2/3 large subunit {ECO:0000313|EMBL:PFG93751.1};
GN   Name=ilvB {ECO:0000313|EMBL:CAL99949.1};
GN   OrderedLocusNames=SACE_0604 {ECO:0000313|EMBL:CAL99949.1};
GN   ORFNames=A8924_1003 {ECO:0000313|EMBL:PFG93751.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99949.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99949.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99949.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93751.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93751.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; AM420293; CAL99949.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93751.1; -; Genomic_DNA.
DR   RefSeq; WP_009945157.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_0604; -.
DR   EnsemblBacteria; CAL99949; CAL99949; SACE_0604.
DR   KEGG; sen:SACE_0604; -.
DR   eggNOG; ENOG4108UY7; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000253152; -.
DR   KO; K01652; -.
DR   OMA; CVDNGGY; -.
DR   OrthoDB; 391134at2; -.
DR   BioCyc; SERY405948:SACE_RS02970-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
PE   3: Inferred from homology;
DR   PRODOM; A4F7C5.
DR   SWISS-2DPAGE; A4F7C5.
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW   Transferase {ECO:0000313|EMBL:CAL99949.1}.
FT   DOMAIN          11..171
FT                   /note="TPP_enzyme_N"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          194..323
FT                   /note="TPP_enzyme_M"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          412..535
FT                   /note="TPP_enzyme_C"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   560 AA;  58318 MW;  F06D7A10BEC005B1 CRC64;
     MTVESFPNAW HAVVDHLREA GVSVLFGLPG DDLEALCALE KAGMRMVLCR DQRNAVCMAA
     GYAIQSGRPG VCVVGKGPAV ANAVGGLLEA RSAGAPVVVL AGGTGTDRRG SGAFQELDQV
     PLVTPVVKWA HRIDHPDRVV PAVEKAFLLA GAGAAGPVYL EIPDHLAHVP VNRFREWTPP
     ALVGATAVPG TGPAVAALEA SRRPVLLVGG GMRHRNGDGA VESFADTAGA AVFSTASGRG
     TASEEHPLFC GLSGLYCPEA AAELWRTTDL VVAVGTALEE TATYGWDGAI GAETPVVQVN
     CDAGGLSTEY GGLRVVGDGA DVLGAWTRAL ASKPPDESWL AAIARCRADV WAHTEDRLAR
     MAADDGLHVA EVLAAIDAVA PPSRILVQEN GLQDMWSYFY PYHVCRTRGG SLVPSEQTTL
     GFGAAASAGA RLAAPDRPVI AFVGDGAFAT VRSELPALRR EGVGVVYVVL RNGGYGWLHA
     QVTSRGLDHR LHPFAADEEE QPEGAVVRQK SQLEDALRDA LATCEQGGGP AIVHIDVQLT
     DTPPGITGLD GDFPSHANEI
//

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