(data stored in ACNUC28527 zone)

SWISSPROT: A4F8D7_SACEN

ID   A4F8D7_SACEN            Unreviewed;       102 AA.
AC   A4F8D7;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 72.
DE   RecName: Full=4a-hydroxytetrahydrobiopterin dehydratase {ECO:0000256|SAAS:SAAS00686659};
DE            EC=4.2.1.96 {ECO:0000256|SAAS:SAAS00686659};
GN   OrderedLocusNames=SACE_0980 {ECO:0000313|EMBL:CAM00312.1};
GN   ORFNames=A8924_1373 {ECO:0000313|EMBL:PFG94107.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00312.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM00312.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAM00312.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG94107.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG94107.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC         (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC         Evidence={ECO:0000256|SAAS:SAAS01115827};
CC   -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC       family. {ECO:0000256|SAAS:SAAS00686664}.
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DR   EMBL; AM420293; CAM00312.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG94107.1; -; Genomic_DNA.
DR   STRING; 405948.SACE_0980; -.
DR   EnsemblBacteria; CAM00312; CAM00312; SACE_0980.
DR   KEGG; sen:SACE_0980; -.
DR   eggNOG; ENOG410842T; Bacteria.
DR   eggNOG; COG2154; LUCA.
DR   HOGENOM; HOG000007680; -.
DR   KO; K01724; -.
DR   OMA; NFAQMVG; -.
DR   BioCyc; SERY405948:SACE_RS04790-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.20; -; 1.
DR   InterPro; IPR036428; PCD_sf.
DR   InterPro; IPR001533; Pterin_deHydtase.
DR   PANTHER; PTHR12599; PTHR12599; 1.
DR   Pfam; PF01329; Pterin_4a; 1.
DR   SUPFAM; SSF55248; SSF55248; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4F8D7.
DR   SWISS-2DPAGE; A4F8D7.
KW   Lyase {ECO:0000256|SAAS:SAAS00686667, ECO:0000313|EMBL:CAM00312.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
SQ   SEQUENCE   102 AA;  11536 MW;  54FC1C87CA3BE51E CRC64;
     MVDMAELLTD DQISSALEHL PEWRHEEGEL TRSVELASFP QAIQVVNRIA EIAEQENHHP
     DIDVRWRNLT FHCVTHSKGG ITQADVSMAQ EIDSAIDAFQ QS
//

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