(data stored in ACNUC1104 zone)

SWISSPROT: A4FGF9_SACEN

ID   A4FGF9_SACEN            Unreviewed;       473 AA.
AC   A4FGF9;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 68.
DE   SubName: Full=EmrB/QacA subfamily drug resistance transporter {ECO:0000313|EMBL:PFG96839.1};
DE   SubName: Full=Transmembrane efflux protein {ECO:0000313|EMBL:CAM03134.1};
GN   OrderedLocusNames=SACE_3863 {ECO:0000313|EMBL:CAM03134.1};
GN   ORFNames=A8924_4251 {ECO:0000313|EMBL:PFG96839.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03134.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM03134.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAM03134.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG96839.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96839.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; AM420293; CAM03134.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG96839.1; -; Genomic_DNA.
DR   RefSeq; WP_009947891.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_3863; -.
DR   EnsemblBacteria; CAM03134; CAM03134; SACE_3863.
DR   KEGG; sen:SACE_3863; -.
DR   eggNOG; ENOG4107SH4; Bacteria.
DR   eggNOG; ENOG410Y3SX; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; NTAFMLT; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; SERY405948:SACE_RS18730-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4FGF9.
DR   SWISS-2DPAGE; A4FGF9.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091, ECO:0000256|SAM:Phobius,
KW   ECO:0000313|EMBL:CAM03134.1};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     21     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     55     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     87    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    112    133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    145    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    211    231       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    237    258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    302       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    314    335       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    368    388       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    417    436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    442    463       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       21    473       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   473 AA;  49526 MW;  214DC3D7B2E15BFE CRC64;
     MAETGPAGAV TEQARDRRWH ALAICLVAGF MTLLDVSIVN VALPSMQQGL DAPPIALAWI
     VSGYALTFGL VLVPAGRLGD DRGRGRMFVI ALLAFTVASA LAGFAQNALW LVIARLLQGA
     AGGMLNPQVL GLMQQLFHGR DRGRAFGLFG AVVGLSTAIG PLLGGVILQF AGNEDGWRWV
     FFVNLPIGAA ALVYALRVLP REDRTERPHN LDLVGVVLLG AGLLCLLLPL VEHSESPWYL
     LAAAPVLLAL FVAWEHWYRV RGYAPLVDLR LLRIGSYSFG TMLGLLYFGG FTSIFFVLAV
     YFQRGLGYSP LEAGLAMTPF AVGSAVSSAV SGRIVYRMGR TLVIIGLVGA LAGLLATDVL
     LGRHFGQMAG LVTALPLLVA GVGSGMVISP NQTVTLSEVD SAQGGTAAGV QQTAQRIGTA
     LGTATASGLF FGALEAGGYD EAISSGLVVS VCFVAAALVL GITERLVVAR RGR
//

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