(data stored in ACNUC4305 zone)

SWISSPROT: A4FUZ3_BOVIN

ID   A4FUZ3_BOVIN            Unreviewed;       440 AA.
AC   A4FUZ3; F1N550;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 112.
DE   SubName: Full=Proteasome (Prosome, macropain) 26S subunit, ATPase, 1 {ECO:0000313|EMBL:AAI23488.1};
DE   SubName: Full=Proteasome 26S subunit, ATPase 1 {ECO:0000313|Ensembl:ENSBTAP00000007135};
GN   Name=PSMC1 {ECO:0000313|EMBL:AAI23488.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000007135, ECO:0000313|VGNC:VGNC:33454};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI23488.1};
RN   [1] {ECO:0000313|EMBL:AAI23488.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI23488.1};
RC   TISSUE=Thalamus {ECO:0000313|EMBL:AAI23488.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000007135}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007135};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000007135, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007135,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family.
CC       {ECO:0000256|RuleBase:RU003651}.
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DR   EMBL; BC123487; AAI23488.1; -; mRNA.
DR   STRING; 9913.ENSBTAP00000007135; -.
DR   Ensembl; ENSBTAT00000007135; ENSBTAP00000007135; ENSBTAG00000005426.
DR   Ensembl; ENSBTAT00000084873; ENSBTAP00000073676; ENSBTAG00000005426.
DR   VGNC; VGNC:33454; PSMC1.
DR   eggNOG; KOG0726; Eukaryota.
DR   eggNOG; COG1222; LUCA.
DR   GeneTree; ENSGT00950000182668; -.
DR   HOGENOM; HOG000225143; -.
DR   OMA; ARCKLRY; -.
DR   OrthoDB; 571919at2759; -.
DR   TreeFam; TF106226; -.
DR   Reactome; R-BTA-1169091; Activation of NF-kappaB in B cells.
DR   Reactome; R-BTA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR   Reactome; R-BTA-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR   Reactome; R-BTA-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-BTA-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-BTA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-BTA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; R-BTA-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-BTA-195253; Degradation of beta-catenin by the destruction complex.
DR   Reactome; R-BTA-202424; Downstream TCR signaling.
DR   Reactome; R-BTA-2467813; Separation of Sister Chromatids.
DR   Reactome; R-BTA-2871837; FCERI mediated NF-kB activation.
DR   Reactome; R-BTA-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR   Reactome; R-BTA-350562; Regulation of ornithine decarboxylase (ODC).
DR   Reactome; R-BTA-382556; ABC-family proteins mediated transport.
DR   Reactome; R-BTA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR   Reactome; R-BTA-4608870; Asymmetric localization of PCP proteins.
DR   Reactome; R-BTA-4641257; Degradation of AXIN.
DR   Reactome; R-BTA-4641258; Degradation of DVL.
DR   Reactome; R-BTA-532668; N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
DR   Reactome; R-BTA-5358346; Hedgehog ligand biogenesis.
DR   Reactome; R-BTA-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
DR   Reactome; R-BTA-5607764; CLEC7A (Dectin-1) signaling.
DR   Reactome; R-BTA-5610780; Degradation of GLI1 by the proteasome.
DR   Reactome; R-BTA-5610785; GLI3 is processed to GLI3R by the proteasome.
DR   Reactome; R-BTA-5632684; Hedgehog 'on' state.
DR   Reactome; R-BTA-5658442; Regulation of RAS by GAPs.
DR   Reactome; R-BTA-5668541; TNFR2 non-canonical NF-kB pathway.
DR   Reactome; R-BTA-5676590; NIK-->noncanonical NF-kB signaling.
DR   Reactome; R-BTA-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-BTA-5689603; UCH proteinases.
DR   Reactome; R-BTA-68827; CDT1 association with the CDC6:ORC:origin complex.
DR   Reactome; R-BTA-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-BTA-69481; G2/M Checkpoints.
DR   Reactome; R-BTA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR   Reactome; R-BTA-75815; Ubiquitin-dependent degradation of Cyclin D.
DR   Reactome; R-BTA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR   Reactome; R-BTA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR   Reactome; R-BTA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR   Reactome; R-BTA-8939902; Regulation of RUNX2 expression and activity.
DR   Reactome; R-BTA-8941858; Regulation of RUNX3 expression and activity.
DR   Reactome; R-BTA-8948751; Regulation of PTEN stability and activity.
DR   Reactome; R-BTA-9020702; Interleukin-1 signaling.
DR   Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000005426; Expressed in 9 organ(s), highest expression level in skeletal muscle tissue.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0036402; F:proteasome-activating ATPase activity; IBA:GO_Central.
DR   GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
DR   GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR   InterPro; IPR005937; 26S_Psome_P45-like.
DR   InterPro; IPR035244; 26S_subunit_4.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032501; Prot_ATP_ID_OB.
DR   PANTHER; PTHR23073:SF77; PTHR23073:SF77; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF16450; Prot_ATP_ID_OB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01242; 26Sp45; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   1: Evidence at protein level;
DR   PRODOM; A4FUZ3.
DR   SWISS-2DPAGE; A4FUZ3.
KW   ATP-binding {ECO:0000256|RuleBase:RU003651};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW   Proteasome {ECO:0000313|EMBL:AAI23488.1};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A4FUZ3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          218..357
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..33
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..102
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  49185 MW;  ACA80782F4F96F49 CRC64;
     MGQSQSGGHG PGGGKKDDKD KKKKYEPPVP TRVGKKKKKT KGPDAASKLP LVTPHTQCRL
     KLLKLERIKD YLLMEEEFIR NQEQMKPLEE KQEEERSKVD DLRGTPMSVG TLEEIIDDNH
     AIVSTSVGSE HYVSILSFVD KDLLEPGCSV LLNHKVHAVI GVLMDDTDPL VTVMKVEKAP
     QETYADIGGL DNQIQEIKES VELPLTHPEY YEEMGIKPPK GVILYGPPGT GKTLLAKAVA
     NQTSATFLRV VGSELIQKYL GDGPKLVREL FRVAEEHAPS IVFIDEIDAI GTKRYDSNSG
     GEREIQRTML ELLNQLDGFD SRGDVKVIMA TNRIETLDPA LIRPGRIDRK IEFPLPDEKT
     KKRIFQIHTS RMTLADDVTL DDLIMAKDDL SGADIKAICT EAGLMALRER RMKVTNEDFK
     KSKENVLYKK QEGTPEGLYL
//

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