(data stored in ACNUC30567 zone)

SWISSPROT: A5D7M5_BOVIN

ID   A5D7M5_BOVIN            Unreviewed;       737 AA.
AC   A5D7M5;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   SubName: Full=ADAM3A protein {ECO:0000313|EMBL:AAI40616.1};
GN   Name=ADAM3A {ECO:0000313|EMBL:AAI40616.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI40616.1};
RN   [1] {ECO:0000313|EMBL:AAI40616.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI40616.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:AAI40616.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; BC140615; AAI40616.1; -; mRNA.
DR   RefSeq; NP_001091635.1; NM_001098166.2.
DR   MEROPS; M12.P02; -.
DR   GeneID; 100048949; -.
DR   KEGG; bta:100048949; -.
DR   CTD; 1587; -.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   HOGENOM; HOG000230883; -.
DR   OrthoDB; 162519at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; A5D7M5.
DR   SWISS-2DPAGE; A5D7M5.
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..737
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002679730"
FT   TRANSMEM        683..702
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          178..376
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   DOMAIN          386..475
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50214"
FT   DOMAIN          610..644
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DISULFID        447..467
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT   DISULFID        634..643
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   737 AA;  82462 MW;  06A9BA4A542BD208 CRC64;
     MLSLLLLLTG LGQLASAGHH SETARLQITV PRKIETNTKD GSISETHVAY SIQIDKKTYT
     LPLEKQSFLD SNLLVYSYNK SRVLYPDSSF IKGHCFYQGY ATEIPNSVVT LSTCSGLRGL
     LQFENVSYGI EPLESSTTYE HVIYPFRDKK SDFSPISADQ SYKILVKSNK DSGVLLKRVL
     KIHVIIDKAL YHYMGSEVAL ASEKIIYVFS LINTMYSQLQ VSVILTSLEI WSDLNKISTD
     GDAHDVLQRF VSWREKSLLQ SSHDLAYLLI YRDHPNYVGA TYHGMACDPK FAAGLALYSK
     MITLEAFSVI FTQLLGIMLG LKYNNNIYEC SCPGIACIMN PEAIRSHGIK FFSSCSIDEF
     KHTTSQPKFE CLQNRTVPKV VPQGRQSICG NGVLEPPEQC DCGSIENCEH TKCCNPLNCV
     LIGNADCGSG PCCGKKTCMI LDRGTECRRS TDPCDFPEIC NGISEFCVPD MRAADLQTCN
     NKSSYCFRGI CQDRTKQCVT LFGKYAKESS YQCTEEVNYQ DDDFGNCLGR TCFFHQHLCG
     KLVCHWTHSA IVSRNDIDVQ YTYLGGHICM SANLRTRRYP DPTVAANGSM CDENKFCDNG
     ACRAIHQYTQ YQDCDPLTKC KGHGICNTRL HCHCDVGYVP PDCEEIALSP GGSIDDGFWN
     LEIDESKTAY LIKRRRASQK NNLMISFYVL LPFFILTAII ALKWNKMKIF WNKEGTISGG
     SPSEISNSNS SQSNSND
//

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